ID A0A1Y4M6R9_9FIRM Unreviewed; 847 AA.
AC A0A1Y4M6R9;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Translation elongation factor G {ECO:0000313|EMBL:OUP63101.1};
GN ORFNames=B5F12_08690 {ECO:0000313|EMBL:OUP63101.1};
OS Pseudoflavonifractor sp. An176.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Pseudoflavonifractor.
OX NCBI_TaxID=1965572 {ECO:0000313|EMBL:OUP63101.1, ECO:0000313|Proteomes:UP000196146};
RN [1] {ECO:0000313|Proteomes:UP000196146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An176 {ECO:0000313|Proteomes:UP000196146};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUP63101.1}.
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DR EMBL; NFKO01000021; OUP63101.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4M6R9; -.
DR Proteomes; UP000196146; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd10912; PIN_YacP-like; 1.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR010298; YacP-like.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF7; ELONGATION FACTOR G-LIKE PROTEIN; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF05991; NYN_YacP; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Elongation factor {ECO:0000313|EMBL:OUP63101.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:OUP63101.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000196146}.
FT DOMAIN 1..225
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 847 AA; 95000 MW; 525B01B009E75385 CRC64;
MKRLTTGIMA HVDAGKTTLT EAMLYLTGNI RRLGRVDHGD AFLDTQELER ERGITIYAKQ
AILRRGDLEL TLVDTPGHVD FSAETERALQ VLDCAILVVS SADGVQGHTE TLWQLLEEAG
VPVFLFVNKM DQPNEGKTAI LKQLEGRLGH GFVDMADPEA RGEGAALCSE ALMERYLSGE
EFTQEELAAL VVQRQLFPVY FGSALQVEGV EELLDGIEAY TLEPEWPQDF GARVFKITRD
ERGERLTWLK VTGGQMRVRE VLHGPNWEEK VNQIRLYSGA KFTAVDVAPA GTVCAVTGLT
HTTAGEGLGA EENWTGPRLE PVLSYQVIPP EGVNASTLLE RLRRLEEEDP QLQVEWEPHA
EQVRVKLMGQ VHREVLEREL RRRFDLDVTF GPGSIVYLET LARPVEGVGH FEPLRHYAEV
HLLLEPLERG AGLQIDTVCS EDVLDGNWQR LILTHLVERQ HVGVLTGSPI TDLKLTLLTG
KGHLKHTEGG DFRQATYRAI RQGLMMGETI LLEPWYTFRL EVPGESVGRA MTDVQRMCGE
FEGPQMRGET AVLTGSLPVS EVGEYWSQVA AYTQGRGRFS CRLDGYRPCH NTQQVVEERG
YDPDRDVDNP SGSVFCDHGA GVHVPWNEVR SRMHVDSGWL PEEERARKAQ PAPQFQRGYA
SQVALDKELE EIFARTYGAV KPRAFHSVKA TTKPKERPWK GLKKRTGKDY LLVDGYNIIH
AWEDLSALAR EDLDGARAKL IDLLRNYQSW RGCQVIVVFD AYKVKGGKGA VEQLGDLYVV
YTKEAETADM YIERTTYQLS RDNRVRVATS DGLEQMIILG HGAQRMSAAE LKYETDQVMA
QIRDTIG
//
