ID   A0A1Y4R8P1_9FIRM        Unreviewed;      1134 AA.
AC   A0A1Y4R8P1;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=B5E84_17070 {ECO:0000313|EMBL:OUQ13640.1};
OS   Lachnoclostridium sp. An14.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1965562 {ECO:0000313|EMBL:OUQ13640.1, ECO:0000313|Proteomes:UP000196089};
RN   [1] {ECO:0000313|Proteomes:UP000196089}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An14 {ECO:0000313|Proteomes:UP000196089};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ13640.1}.
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DR   EMBL; NFLE01000041; OUQ13640.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4R8P1; -.
DR   OrthoDB; 9758506at2; -.
DR   Proteomes; UP000196089; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR049035; ADDB_N.
DR   InterPro; IPR014140; DNA_helicase_suAddB.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   NCBIfam; TIGR02773; addB_Gpos; 1.
DR   PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR   PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR   Pfam; PF21445; ADDB_N; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:OUQ13640.1};
KW   Helicase {ECO:0000313|EMBL:OUQ13640.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196089}.
FT   DOMAIN          277..567
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
SQ   SEQUENCE   1134 AA;  129234 MW;  FEE230C15B386AEE CRC64;
     MALQFIMGGS GAGKTRLLYE RLIEESVKRP KQQFVVIVPE QFSMQAQKEV VSLHPRRGTM
     NIDIMSFERL AYRVFEELGV VNPAVLDDMG KSMVLRKVAA LKGRQLGIFR GHLGQAGFIG
     QLKSMVSELY QYGVTPERLE EMESQAQSPL LKAKLADLAV VCRGFREYIE ERFITAEEIL
     GELCKVFPRS ERMRDSVVVL DGYTGFTPVQ YRLLEQMLLC CRDVKLCVTV ERAAKPYERG
     GVQQLFFMSK ETVCRLNELA VKNRVKVEKD CWLETRPYPR FAGRELDFLE KNLYRYSRKA
     WEEATEDVLV YRALNPKEEI ALVANQIEKL VRREGLRYRD VAVVTGDLES YGKEAAFQFG
     EKGIPFFLDD KKSILENPLV EYIRAALEAV RRDFSYEAMF RYVKCGLAAE PEERELCDRM
     ENYCLALGIR GFKRWSAPWE LIYRNGKQIN MEELNAFREK IAAPLFHLRE SFRREDATVR
     SMTEALVEFL TETEAERKIL DWSERFREQG EYQLADEYSQ VYGLVMELFD RLAALLGEET
     AGQKEYGEIL DAGFGEIKVG VIPATVDRVA VGDITRTRLT HVKALFFVGV NDGIVPAKRE
     KGGILSETER EFLEACDLEL APTARKEGFL QRFYLYLALT KPERKLILSY ASMNQAGKGL
     RPSSLIRELE KLFPRLTERE AAGELSVVSE LEGKKVLAEG LRESREQADP KFLELYRYFW
     NREENREELS RLVEAAFYSY EERGIGRAAA RELYGKILSG SVTRLEQYEA CAYAHFLSYG
     LELRERQEYE LKAADVGNLF HGAIDLSFKK AAERGIRLQE LDGAGRDALA DAAVAEAIAG
     YGGNIMSSSA RNAYLAGKVG RITRKTLWAL AEQLKKGEFT PAGFEVSFSA IDNLEAMKIS
     LTEDEALHLQ GRIDRMDLCE DEKHVYVKII DYKSGSTSFD LAALYYGLQL QLVVYMDAAM
     ELLERRNPDK EIVPAGVFYY HIDDPMVDGE EAATKEDVDR LVLKKLRMDG LVNSELEVIS
     LMDREIEKAS DVIPVAIKDG LVQEAKSSVA NRERFGALRR FVRGKLKGAG LEILDGAMGI
     GPYKQGRRTA CDYCPYHGVC GFDRRLPGYE YRKLKDKKPE EIWQEIEGGD REEQ
//