ID A0A1Y4RSJ8_9FIRM Unreviewed; 720 AA.
AC A0A1Y4RSJ8;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=B5E84_05990 {ECO:0000313|EMBL:OUQ19812.1};
OS Lachnoclostridium sp. An14.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1965562 {ECO:0000313|EMBL:OUQ19812.1, ECO:0000313|Proteomes:UP000196089};
RN [1] {ECO:0000313|Proteomes:UP000196089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An14 {ECO:0000313|Proteomes:UP000196089};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ19812.1}.
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DR EMBL; NFLE01000007; OUQ19812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4RSJ8; -.
DR OrthoDB; 9764149at2; -.
DR Proteomes; UP000196089; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00357; CSP; 2.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000196089};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 631..711
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 720 AA; 81227 MW; 6BB592618B0D75AB CRC64;
MKQELLEERK KRMAELLADP AYVPMKLKEL AILLGIPKEQ RDELKEVMDA LVAEGKAGIS
KKGKYGRPES FSLTGVFSGT SKGFGFVAIE GWAEDVFIPP DKTGGALNGD TVRIVTENGK
KGRRTEGTVI RVLERANEKL VGYYQKSKNF GFVVPDNQKI GCDVFIPQGK DMGAVTGHKV
VVNITDFKDG KQNPEGKIVE ILGHINDPGV DILSIVRAYE LPEEFPDEVM AQVEGQIPDA
VPEKDKAGRL DLRDVPMVTI DGEDAKDLDD AVSLSKETGG GRTVYRLGVH IADVSHYVTE
NSPLDKEALR RGTSVYLVDR VIPMLPHRLS NGICSLNAGE DRLALSCLME FDGAGRMVSH
RIAETVIRVD RRMSYTDVNQ IITYEDQETM ERYEELVPMF FLMKELADLL RANRMKRGAI
DFDFPESKIL LDEKGKPLEI RPYERNAATR LIEDFMLAAN ETVAEDYFWQ EVPFLYRTHD
VPDPEKMKSL AVFINNFGYT VRSQKGEIHP GELQKLLGKI EGTPEEALLS RLVLRSMKQA
KYTVINSGHF GLAAKYYTHF TSPIRRYPDL QIHRIIKENL RGGLSGKRMG HYERLLPEVA
VKTSALERRA DEAERETDKL KKCEYMSRFV GEEFDGVISG VTSWGFYVEL PNTVEGLVRV
NDLTGDYYLF DEHSLELKGE MTRRTFKLGQ KVRVRVTGTD KFSRTVDFAW VGDCPAKQEE
//
