ID A0A1Y4RWA1_9FIRM Unreviewed; 518 AA.
AC A0A1Y4RWA1;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Citrate lyase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE Short=Citrase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE EC=2.8.3.10 {ECO:0000256|PIRNR:PIRNR009451};
DE EC=4.1.3.6 {ECO:0000256|PIRNR:PIRNR009451};
DE AltName: Full=Citrate (pro-3S)-lyase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE AltName: Full=Citrate CoA-transferase subunit {ECO:0000256|PIRNR:PIRNR009451};
GN ORFNames=B5E84_01110 {ECO:0000313|EMBL:OUQ21887.1};
OS Lachnoclostridium sp. An14.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1965562 {ECO:0000313|EMBL:OUQ21887.1, ECO:0000313|Proteomes:UP000196089};
RN [1] {ECO:0000313|Proteomes:UP000196089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An14 {ECO:0000313|Proteomes:UP000196089};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + citrate = (3S)-citryl-CoA + acetate;
CC Xref=Rhea:RHEA:19405, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57321; EC=2.8.3.10;
CC Evidence={ECO:0000256|PIRNR:PIRNR009451};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = acetate + oxaloacetate; Xref=Rhea:RHEA:10760,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089; EC=4.1.3.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR009451};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR009451}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ21887.1}.
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DR EMBL; NFLE01000001; OUQ21887.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4RWA1; -.
DR OrthoDB; 9767643at2; -.
DR Proteomes; UP000196089; Unassembled WGS sequence.
DR GO; GO:0009346; C:ATP-independent citrate lyase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008815; F:citrate (pro-3S)-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008814; F:citrate CoA-transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 2.
DR InterPro; IPR006472; Citrate_lyase_asu.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01584; citF; 1.
DR PANTHER; PTHR40596; CITRATE LYASE ALPHA CHAIN; 1.
DR PANTHER; PTHR40596:SF1; CITRATE LYASE ALPHA CHAIN; 1.
DR Pfam; PF04223; CitF; 1.
DR PIRSF; PIRSF009451; Citrt_lyas_alpha; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR009451};
KW Lyase {ECO:0000256|PIRNR:PIRNR009451, ECO:0000313|EMBL:OUQ21887.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000196089};
KW Transferase {ECO:0000256|PIRNR:PIRNR009451}.
SQ SEQUENCE 518 AA; 55627 MW; 1478E72C60F9CF42 CRC64;
MINAVGREIP EQVLEATGKE VFKGAYAYDN YEYKKAAPTV RAMVDPTRSK MVSSIREALE
KCGIKDGMVL SFHHHFREGD YVVNMVMEEV HNMGIKDITI CASSLGKANN AIVPYIEDGT
IVGIQSSGVR GKIGEAISTG KLRDLAIMRS HGGRVRAIET GEVHIDIAFI GAPTCDEYGN
CRPNGGKSDC GVLSYAMADA KYADKVVAVT DCLVPFPNVP ASISMSDVDY VCVVDEIGNP
AKIATGAAKP TTDVRKLMMA DYCTQFVINT PYFKDGFSYQ TGVGGASIAS TISLGKIMEE
RGIQMGFGVG GITTPMCDLL EKGLIRTIVD TQDFDLGAIE SIKKNPNHVE ISASEYANPM
NKGAYVNRLD FVILAALEVD VNFNCNVVVG SDGMITGAQG GHPDTAAGAK CTIVIAPLLQ
GRIPAICTNV TTVTTPGETV DVVITDYGIA INPKRQDLIE CMKGVNLPFR TIEELRDIAY
SIVGEPAPVE FDDRVVGIIE SRDGTVLDVV RKIKEVEL
//
