ID A0A1Y4S012_9FIRM Unreviewed; 840 AA.
AC A0A1Y4S012;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:OUQ23194.1};
GN ORFNames=B5E77_15970 {ECO:0000313|EMBL:OUQ23194.1};
OS Lachnoclostridium sp. An131.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1965555 {ECO:0000313|EMBL:OUQ23194.1, ECO:0000313|Proteomes:UP000199743};
RN [1] {ECO:0000313|Proteomes:UP000199743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An131 {ECO:0000313|Proteomes:UP000199743};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ23194.1}.
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DR EMBL; NFLI01000026; OUQ23194.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4S012; -.
DR OrthoDB; 9804747at2; -.
DR Proteomes; UP000199743; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR037522; HD_GYP_dom.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR031621; HisKA_7TM.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF13487; HD_5; 1.
DR Pfam; PF16927; HisKA_7TM; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51832; HD_GYP; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199743};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 491..625
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 642..837
FT /note="HD-GYP"
FT /evidence="ECO:0000259|PROSITE:PS51832"
FT DOMAIN 664..786
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 840 AA; 95824 MW; 8BDE871D855ABFE6 CRC64;
MHSYRYISII ALFFYCFIFL TFLAAKKVKI VKYFLFLVAV MMCWTAGSAF MRLQLYPSYV
FWYHVSLGGL LLTPYAYFLF ANAFGDREER FFNYLYGILL LGLFCLNIPD GIFLHWPELI
LKNGEAAFEY RYTWRVAILF GAAAVVLLHS FANVVRICRE DSWYKKQFQP IIIGIACLFA
GHLALLVPVF RGFPIDLVLG IVNALFLIYA LLSRRLFQLK LLASESSCYG MGLLLTFLLY
YNLMPDINAQ LVSRFPVASE YTILIFAVLF LLTFCLLVFL WRKIIENLFI REEEQQTEKI
RKYNNLVARS LRLEEILAET VEIIQETVES VNIYICIQEH GDGDYQARYS NQPLNDLSFT
IRKDNPLIRI LERNDGVLMR EFQAMIGYKS MWESEKRSFQ NLKIEACVGL RDKEKIVGVV
LLSNPPGNRK ISRTDMDMAL TIASSASIAI KNARLYETAC YEARTDELTK LLNRKYFFEL
LNREFEANTE GSLALAIINI DDFKLYNQLY GTQAGDNALR RIAEIIKSSV GESGYAARYS
GKEFAVLLPK YDVFSARNLV KSIQKQIFQM TDNTVDYKLK VLTVSVGISA APYAAKTPKE
LLDNADMAVN HVKRTGKNGI EIFDTILRES TAQEDVTDHR NIYREYESTI YALTAAIDVK
DHYTFSHSNN VAYYATSLAK EMNLNSDMVE IIRQAALLHD VGKIGISEAI LNKAGKLTEE
EYETIKGHVE ASIGIIRHLP SLDYVIPAVI GHHERYDGRG YPRRIAGENI PLSARILCVA
DSFDAMTTRR CYKDVIPEDR ALEILEEEAG RQFDPKLVQI FVCGMREGRI QIAGEAAAGK
//
