ID   A0A1Y4S0Y9_9FIRM        Unreviewed;       454 AA.
AC   A0A1Y4S0Y9;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN   ORFNames=B5E80_09555 {ECO:0000313|EMBL:OUQ23526.1};
OS   Flavonifractor sp. An135.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Flavonifractor.
OX   NCBI_TaxID=1965558 {ECO:0000313|EMBL:OUQ23526.1, ECO:0000313|Proteomes:UP000196472};
RN   [1] {ECO:0000313|Proteomes:UP000196472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An135 {ECO:0000313|Proteomes:UP000196472};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC       {ECO:0000256|ARBA:ARBA00005163}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ23526.1}.
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DR   EMBL; NFLG01000015; OUQ23526.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4S0Y9; -.
DR   OrthoDB; 9800864at2; -.
DR   UniPathway; UPA00223; -.
DR   Proteomes; UP000196472; Unassembled WGS sequence.
DR   GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06113; citrate_synt_like_1_2; 1.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000196472};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT   ACT_SITE        332
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        391
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   454 AA;  51083 MW;  C7DAE60E9ED5CE3B CRC64;
     MATNPNYGRI TPEIEAMAEM TRSNSSIDPA DYVRYDVKRG LRDLNGKGVV AGLTEVSDII
     AKKVVDGKEV PCDGELYYRG INVQDLVNGV LKEKRFGFEE TAYLLMLGRL PNAKELQEFQ
     AQLAYYRSLP NNFVRDVILK APSGDIMNSL ARSVLNLVSY DENADDISLP NVMRQCMQLV
     AVFPLLAVYG YQAYHYKEGN SLYIHAPQPQ HSTAETILSL LRPDSAYSYW EAHVLDICLI
     LHAEHGGGNN STFTTHVVTS SGTDTYSCMA AALASLKGPR HGGANIKVIR MFEDMKQVVK
     DWKDEDEVRH YLQALLDKQA FDKSGLIYGM GHAVYSLSDP RANILHGMVE KLSREKGRME
     EYELYSMVER LGPEVIAGER KMYKGVSANV DFYSGFVYHM LDLPLELYTP LFAMARVAGW
     GAHRIEELIN MGKIIRPAYQ YVGQHQPYHP LSDR
//