ID A0A1Y4S3L7_9FIRM Unreviewed; 575 AA.
AC A0A1Y4S3L7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=B5E80_09205 {ECO:0000313|EMBL:OUQ23692.1};
OS Flavonifractor sp. An135.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Flavonifractor.
OX NCBI_TaxID=1965558 {ECO:0000313|EMBL:OUQ23692.1, ECO:0000313|Proteomes:UP000196472};
RN [1] {ECO:0000313|Proteomes:UP000196472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An135 {ECO:0000313|Proteomes:UP000196472};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ23692.1}.
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DR EMBL; NFLG01000014; OUQ23692.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4S3L7; -.
DR OrthoDB; 9813151at2; -.
DR Proteomes; UP000196472; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45453; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR PANTHER; PTHR45453:SF1; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF13188; PAS_8; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OUQ23692.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000196472};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 148..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 176..229
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 234..275
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 360..575
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 575 AA; 61969 MW; 7AAA94437A89F41F CRC64;
MKKRLTATTF LIVLVALLVS NAMGVWFLFN QERDDSLESL KELLILMDSQ SQITNAQAAA
EQFRQAAPDK RLTIIDTDGT VLVDTDADAD SLENHASRPE VASALATGWG EDTRASDTVG
VPMLYVAKRF TDGMIGRASM PLSSIDSLVW RGAAGLLAAS VVALLLVLAL SRRMAQRAVA
PLGAVSDALS SVLAGSAPTS LDAYRSDDEL RPILRYIDKL VERLGDSIQS LTSERDKVNL
ILDCMDEGFL LLDEKGGLLA SNRAARELFG VPEDSSDLSG LLIHTRSRRL REALEQCHSQ
KTQVVLDVDD LPLPGRSLRF FLSPVSGQQY EGQRVGTSIL LSDVTELKRA EHIRNDFTAN
VSHELKTPLT SIKGFADMLS SGMVTEPADQ KRFSSLIGVE VDRLIALIND ILKISELDSV
AIDQEGASAP LLATAQEVAG LLELKAGEQQ VTITVSGEEC TAAISPDRLR EVILNLAENG
LKYNRPGGSL TITTACEGDQ AVLTVADTGI GIPPEALPRI FERFYRVDPG RARKAGGTGL
GLAIVKHIVA LYGGRIQVDS QVDQGSTFRI TLPRA
//
