ID   A0A1Y4S7L6_9FIRM        Unreviewed;       980 AA.
AC   A0A1Y4S7L6;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=B5E77_10115 {ECO:0000313|EMBL:OUQ25824.1};
OS   Lachnoclostridium sp. An131.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1965555 {ECO:0000313|EMBL:OUQ25824.1, ECO:0000313|Proteomes:UP000199743};
RN   [1] {ECO:0000313|Proteomes:UP000199743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An131 {ECO:0000313|Proteomes:UP000199743};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ25824.1}.
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DR   EMBL; NFLI01000011; OUQ25824.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4S7L6; -.
DR   OrthoDB; 2049726at2; -.
DR   Proteomes; UP000199743; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR47508; SAM DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR47508:SF1; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13023; HD_3; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199743}.
FT   DOMAIN          1..126
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   980 AA;  114561 MW;  C7896E22730BDC2B CRC64;
     MSHVFISYSS HEMETATRVY TYLESKGIPC WIAPRNVEAG SNYATQIVKA IKSCDALVLL
     ASEYTNASGH VSNEVSLAFD CKKVIIPFKI QNIQFTDEYV YFLGRKHWIE AHEDMNQGLQ
     QLYHTLLGFV KEQPLGSMPD VPGIEKIIQP EADEIMVAQD YTREEIAELL MEHTEKYSYC
     LRTRLTDREG YLRFKANALG LFQETVQTFY YNKRLSADTD IIQILSEELT KGSNINVRVQ
     GLPGSAKNMI LQLIFYELLY RFRKGESNYL PIYISASYYE KLPYNPENLH GQMKEFLEKE
     CADYLGYLSI YKEIQPVIMV EAIREHYVAK VSPETVLDEI LRPLGKFNRI TAVDTGLIKN
     RMRLKKVIPL VGEPRGYLLQ THPVPIERKS SVLHIIRCIM EMYDYPFKTE TIYEILGQMK
     YSQIDIFLIR LVAKELRSAY GVTEIHMTDM YYKMALNELY ADEEKLRKAS EELFRYVVDD
     TLDVKSLVYD GDLWLLPHKH GSYLEFMMAY YFSYRIDNQE LFKDYSFFRT MLTSNANHFM
     SSMLSDSYGL QEKMLGFVIE NYENFDIHQK SNGAYWIGRL TYKNLTNQAV EFLMKEFVRL
     KPVVKPDSRE YQENYDNHFL FRAVCTGLFM QGQVQILDEY LGILIGNKVA NAINRGATIE
     YFGDNYQMVA HDAYYLDTDL STGVQALEEL NKRIVIAFRN GKTQYPEYNL VTMLMLLQAR
     MQSFSTLTNF NLTYYIKKAL ENLKIYQSRP QNVISGKIMN YFASVQDDFE RYVATEGFDI
     GSNIYNKCRS LRDVKRKQWE AYGVEDPESV SEHTFSAWIL AALFLPAHME TEGYIKSEVL
     DMILIHDMAR YETEGHETDR GETKETLYEK DFVSRKLFLK GTYPNVASLT YYYNIWTGYR
     NGININSRLA RDIVLLQTVY TFCEYCTRYP EKFTKKDIDS WISEKANLIT ETGYELFERL
     IEKNPDYIKL IEVHQNESQM
//