ID   A0A1Y4T0U5_9FIRM        Unreviewed;      1406 AA.
AC   A0A1Y4T0U5;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=2-hydroxyglutaryl-CoA dehydratase {ECO:0000313|EMBL:OUQ34811.1};
GN   ORFNames=B5E75_05770 {ECO:0000313|EMBL:OUQ34811.1};
OS   Massilimicrobiota timonensis.
OC   Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae; Massilimicrobiota.
OX   NCBI_TaxID=1776392 {ECO:0000313|EMBL:OUQ34811.1, ECO:0000313|Proteomes:UP000195305};
RN   [1] {ECO:0000313|Proteomes:UP000195305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An13 {ECO:0000313|Proteomes:UP000195305};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ34811.1}.
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DR   EMBL; NFLJ01000013; OUQ34811.1; -; Genomic_DNA.
DR   OrthoDB; 9802715at2; -.
DR   Proteomes; UP000195305; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014}.
FT   DOMAIN          6..256
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          322..574
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          671..889
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1406 AA;  157882 MW;  AA7AF101166A1426 CRC64;
     MSQYYLGIDV GSTTVKAYLT DEKDVCLFSR YVRHNSDVRN TILTLLEEIH QEYPGINIYP
     VITGSGGLSI SQSLNVKFVQ EVIACTKTIE TYIPQTDVAI ELGGEDAKIT YFEGSLEQRM
     NGTCAGGTGA FIDQMATLLQ TDASGLNELA KNHQRIYPIA SRCGVFAKTD VQPLINEGAR
     KEDIAASIFQ AVVNQTISGL ACGKPIKGKV AFLGGPLYFL SELRQRFIET LELQDDDIIF
     PDNSQLFVAM GAALNAKDVE ESLSLEKLIH DLKVLKDNGT EAAHTLEPLF HNEDELRGFR
     DRHLQAMTKK RNLKKYQGNI YVGIDVGSTT SKVVLIDDEG SILYSFYNSN EGNPLDLIIR
     IMKEIYDLIP EGCHIQKTGV TGYGEALIKA ALKVDYGEVE TIAHYTAAKH FEPDVDFILD
     IGGQDMKAIT IKDEVIQDIT LNEACSSGCG SFLETFAHSL GYEIDEFAEM ALMSKHPLDL
     GSRCTVFMNS KVKQAQKEGA SLADISAGLS YSVIKNALYK VIKLRSKDQI GKNVVVQGGT
     FYNEAVLRAF EKEAGIEVIR PDIAGLMGAY GMATIAKEKD DGKGTTLLTR EELEHLTYQN
     SMKNCGKCTN NCMLTITSFN DGREFISGNR CERGANLPLK SKSLPNLFDY KYRRVFNYRS
     LPIEDAPRGI VGIPRALNMY ENYPFWHTFF TELKFRVVLS SRSSKAIYEK GIESIPSESA
     CYPAKITHGH IENLIARGVP FIFYPSVAYE RMENENAGNH YNCPVVASYP EVIRNNVDNL
     EQKNIKFKNP FISLNNKKTL FNVLKEELSE FHITDQELHH AIDKAYEELD HCQQDIRAEG
     KRAMEYMREN HMQGIVLAGR PYHVDPEINH GIPDLITSEG FVVLSEDSVC YLDEEHLKLR
     VVDQWTYHSR LYKAASFVSS QKDLQLIQLT SFGCGLDAVT ADQVAEILKA RNKIYTLIKI
     DEGSNLGAIR IRIRSLKATI EKKEDIIDLS KKYEQVKVPF TKQMKEDRYT ILCPQMSPIH
     FQFVETAMNS EGYNFEVLPS VDKDAVEQGL KYVNNDACYP SILVVGQMMN ALNSGKYDLN
     KVALIISQTG GGCRATNYIA FIRKALKDAD MEQIPVISAN LSGLESNPGF KITYKIAKKV
     IIGAMYGDLF MRVLYRVRPY EKVKGSANKL YESWVAKCQE NVKNGSMKEF KKNVYQIVKD
     FDELPLLDIK KPRVGLVGEI LVKFHPTANN EIVKIIESEG GEAVMPDLID FFQYCFYNTW
     YEHEHFDASQ SSVWLCNFAI WFVDFLRKDM IKALRDSKRF DPPTPIDQIA KKASEVVSIG
     NQTGEGWFLT GEMIELIEEG APNIVCMQPF ACLPNHVTGK GVIKALRKKY PQSNIVAVDY
     DPGASEVNQL NRIKLMLSTA FKNMKS
//