ID   A0A1Y4T3S4_9FIRM        Unreviewed;       649 AA.
AC   A0A1Y4T3S4;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:OUQ36290.1};
GN   ORFNames=B5E75_01730 {ECO:0000313|EMBL:OUQ36290.1};
OS   Massilimicrobiota timonensis.
OC   Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae; Massilimicrobiota.
OX   NCBI_TaxID=1776392 {ECO:0000313|EMBL:OUQ36290.1, ECO:0000313|Proteomes:UP000195305};
RN   [1] {ECO:0000313|Proteomes:UP000195305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An13 {ECO:0000313|Proteomes:UP000195305};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ36290.1}.
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DR   EMBL; NFLJ01000003; OUQ36290.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4T3S4; -.
DR   OrthoDB; 9806130at2; -.
DR   Proteomes; UP000195305; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd01987; USP_OKCHK; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR038318; KdpD_sf.
DR   InterPro; IPR025201; KdpD_TM.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR   PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR   PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR   Pfam; PF13493; DUF4118; 1.
DR   Pfam; PF02702; KdpD; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OUQ36290.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        372..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        396..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        418..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..211
FT                   /note="Signal transduction histidine kinase osmosensitive
FT                   K+ channel sensor N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02702"
FT   DOMAIN          373..475
FT                   /note="Sensor protein KdpD transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13493"
SQ   SEQUENCE   649 AA;  74042 MW;  01237474BFD7EDEA CRC64;
     MKKGRLKIFF GYCAGVGKTF AMLEAAHQKS VQGVDVVIGY IEPHDRKETT DLIYGLEQIP
     KKKIIYRDRL FYEFDLDGAL KRHPQLILVD ELAHTNVHGS RHQKRYSDIE ELLRAGIDVY
     TTVNVQHLES LHDIVESITR IKVNERIPDH VFDDADDVKL VDIEIDDLIE RLKEGKIYHK
     QQAKRALEHF FIRDNLTALR EITLRRCADR VNIVTAKQNQ PFAKEHILVC IGSSPTNQKV
     IRTASRMAQA FHADFTALYV ETSKSNNLSK KALAQLQSNL NLAKHLKADI VSTYGDDVAF
     QIGQYAKTSG VSKLVLGRSY QKPTLIKRST IVDQLTMNAP NLEIYIIPDH RSTAQKKSVD
     LSKFIKFSLK ETILALSIFL ITTLLGFIFY EIHVNTTNII LLYVLASCFI GIVTYYPIYN
     LISTFLSIIA INYFFIDPRF TFNMSSSDYP FIFIVMFIVS ISISTMAHKL KKENLLASIH
     AHSMDILLET SQNLQTSNSY QDIMNITCFQ LYKMLNRIII FYPVKNNTLQ KPMIYGPHIT
     SDIKREYINH KELAVAQWVL VNNKNAGVST STLPAAKGLY LAVRKKDNIF AVIGIAMEQG
     EDLAPYEKAL LKAILNEIAL AIDAIYKQES HNEMILKQQL NESLEHEDM
//