ID A0A1Y4TVQ3_9FIRM Unreviewed; 361 AA.
AC A0A1Y4TVQ3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Site-specific integrase {ECO:0008006|Google:ProtNLM};
GN ORFNames=B5E62_09835 {ECO:0000313|EMBL:OUQ49639.1};
OS Lachnoclostridium sp. An118.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1965547 {ECO:0000313|EMBL:OUQ49639.1, ECO:0000313|Proteomes:UP000199786};
RN [1] {ECO:0000313|Proteomes:UP000199786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An118 {ECO:0000313|Proteomes:UP000199786};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules.
CC {ECO:0000256|ARBA:ARBA00003283}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC {ECO:0000256|ARBA:ARBA00008857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ49639.1}.
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DR EMBL; NFLQ01000010; OUQ49639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4TVQ3; -.
DR OrthoDB; 9785687at2; -.
DR Proteomes; UP000199786; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008907; F:integrase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR004191; Integrase_Tn916-type_DNA-bd_N.
DR PANTHER; PTHR30629; PROPHAGE INTEGRASE; 1.
DR PANTHER; PTHR30629:SF2; PROPHAGE INTEGRASE INTS-RELATED; 1.
DR Pfam; PF02920; Integrase_DNA; 1.
DR Pfam; PF14659; Phage_int_SAM_3; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000199786};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 66..149
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 170..361
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
SQ SEQUENCE 361 AA; 42375 MW; FFE907F7F14AD48C CRC64;
MGKDLKGKEL GTGISQRADG NYMARYVDRY KKRHTFYGRD LKALRRRLEK ERYESEQGII
SSEGNISLAE WFEEYLKLYK EGKVKDTTLF RIRQTFSPCK KNVLGMMRLR EIRADHVQRL
INELDEKGFT YGTIRLLKSL LNEMFKKAVG NGYMLINPCD AVVMPRKVTY EPRFLTEREQ
EMFLEVAREY YHYDIFCVSL SMGARIGEVL GLKWSDIDFD KKMIHIQRTL HYGKVQENES
CHFFFTSPKT TTSDRCIPLL PETEMILKRV RKRQLRNRML YGSQSATTPP FDDMVFTTQQ
GAPVRYGDVN RTIKSVVLKA NLQEEELAGF EKREPFVLKP FSPLLSIEFY RAGCAQRLRH
L
//
