ID   A0A1Y4U107_9FIRM        Unreviewed;       958 AA.
AC   A0A1Y4U107;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:OUQ50863.1};
GN   ORFNames=B5E62_06985 {ECO:0000313|EMBL:OUQ50863.1};
OS   Lachnoclostridium sp. An118.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1965547 {ECO:0000313|EMBL:OUQ50863.1, ECO:0000313|Proteomes:UP000199786};
RN   [1] {ECO:0000313|Proteomes:UP000199786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An118 {ECO:0000313|Proteomes:UP000199786};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ50863.1}.
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DR   EMBL; NFLQ01000006; OUQ50863.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4U107; -.
DR   OrthoDB; 9757901at2; -.
DR   Proteomes; UP000199786; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199786};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          60..322
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          612..931
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   958 AA;  105841 MW;  ADCCB758A5166332 CRC64;
     MWERIKSGIY ELFQRRAVVS IIIFCVMFSI LVGRLFQLQI VNGQSYLEDY TIQIQKTRTI
     QGTRGNIYDR NGNLLAYNEL AYSVTIEDNG VYNTTAEKNE ALNEEITRII EIVEGNGDSV
     ISDFSIVLDA NNEYQFSMTD ETQRLRFVAD VFGESYIDSL DDEQRNMSAA EIIDYLCTDE
     TYGYGIDQDA LDRSQVLKMV NIRYAIGLNS FQKYIPTTVA EDVSDETVAE IMEHLNELQG
     VDIAEESLRR YTDSKYFANL IGYTGQISQE EYNALGEEEK EQYDLTDTVG KSGLEQVLDS
     TLQGDKGEVK LYVNSVGRVI DTVGETEPKA GNDVYLTIDA NLQKAAYDIL EQELAGILLS
     RMQDILDYDR TQSEDAADVI VASGDAYNAF IDNDIVDMSH FSAEGAGAAE QSVYGKFAPY
     KEQVLSQLTS IMQDGNASAY RDMSREWQAY LSHVVNEVLT GENGVIMSDA IDTDDETYQQ
     WRNEETINIY TYLNYAISQN WVDASKLQAY LSSEGNYSDS SEVYSAMISY VTDRLSSSTD
     FDKLIYQYMI KAGTVTGREL CMILYEQGVL PMDETQYNNL ASGATGAYDF LRSKIQSLEI
     TPGQLGLEPC RGSVVITDTD SGDVLACVSY PGYDNNRLAN TMDSEYYNEL NTSTSQPFYN
     SATQETTAPG STYKPLVAVA GLTEGAIDTS TTVYCDGNFD VISPEVHCWV YPAGHGTMNV
     VSGITNSCNE FFNNIGYQLG MQTDGTYSSE YGLERLAKYA ELFGLNETSG LEIPEMDPKV
     SDEDSVRSAM GQGTNNYTTS QLARYITAVA NKGTLYELTL LDRVENVDGE VVEEFQNGEA
     RTIEGVSSST WDAVHAGMEG VVQNSSVFTA INASSMSVSG KTGTAQQSTT HADHGLFVGF
     APSDNPEIAM AIRIANGYSS TYASEVGSNI FQYYYQITDS AQLITGQAAE ITVNTSGD
//