ID   A0A1Y4UEK2_9FIRM        Unreviewed;       241 AA.
AC   A0A1Y4UEK2;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=pre-crRNA processing endonuclease {ECO:0000256|PIRNR:PIRNR029950};
DE            EC=3.1.-.- {ECO:0000256|PIRNR:PIRNR029950};
GN   ORFNames=B5E58_12340 {ECO:0000313|EMBL:OUQ55385.1};
OS   Tyzzerella sp. An114.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Tyzzerella.
OX   NCBI_TaxID=1965545 {ECO:0000313|EMBL:OUQ55385.1, ECO:0000313|Proteomes:UP000196526};
RN   [1] {ECO:0000313|Proteomes:UP000196526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An114 {ECO:0000313|Proteomes:UP000196526};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA).
CC       {ECO:0000256|PIRNR:PIRNR029950}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC       Subtype I-C/Dvulg subfamily. {ECO:0000256|PIRNR:PIRNR029950}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ55385.1}.
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DR   EMBL; NFLT01000028; OUQ55385.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4UEK2; -.
DR   OrthoDB; 5621871at2; -.
DR   Proteomes; UP000196526; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-UniRule.
DR   GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.2660; -; 1.
DR   InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR   InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR   InterPro; IPR010155; CRISPR-assoc_prot_Cas5d.
DR   NCBIfam; TIGR01876; cas_Cas5d; 1.
DR   NCBIfam; TIGR02593; CRISPR_cas5; 1.
DR   Pfam; PF09704; Cas_Cas5d; 1.
DR   PIRSF; PIRSF029950; Cas_CT1134; 1.
PE   3: Inferred from homology;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW   ECO:0000256|PIRNR:PIRNR029950};
KW   Endonuclease {ECO:0000256|PIRNR:PIRNR029950};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR029950};
KW   Nuclease {ECO:0000256|PIRNR:PIRNR029950};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196526};
KW   RNA-binding {ECO:0000256|PIRNR:PIRNR029950}.
SQ   SEQUENCE   241 AA;  28264 MW;  15F996950A3C10B9 CRC64;
     MYGFKIIIEG DYACFTRPEM KVERVSYDVP TPGALEGILK SIYWKPAIRY VIDKIVVFND
     INFMNVRRNE VKEKVSYNAV KNQMKGKTSS PYIYTSDVRS QRSAMILKNV KYGVEFHFEL
     TGIKNDNEFE GEKKHYNIIK RRIEKGQYFR VPCLGCSEFP VKKIYMIEEF NYEDISSSIV
     EMGDVDLGFM NYKVVFNDKG IPINGDWENP KFSDKAHTVY YRPHMINGVI DVFKYREGFK
     C
//