ID   A0A1Y4UKR6_9FIRM        Unreviewed;       458 AA.
AC   A0A1Y4UKR6;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=2-isopropylmalate synthase {ECO:0000313|EMBL:OUQ58420.1};
GN   ORFNames=B5E58_07300 {ECO:0000313|EMBL:OUQ58420.1};
OS   Tyzzerella sp. An114.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Tyzzerella.
OX   NCBI_TaxID=1965545 {ECO:0000313|EMBL:OUQ58420.1, ECO:0000313|Proteomes:UP000196526};
RN   [1] {ECO:0000313|Proteomes:UP000196526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An114 {ECO:0000313|Proteomes:UP000196526};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ58420.1}.
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DR   EMBL; NFLT01000006; OUQ58420.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4UKR6; -.
DR   OrthoDB; 9804858at2; -.
DR   Proteomes; UP000196526; Unassembled WGS sequence.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd07947; DRE_TIM_Re_CS; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42880; HOMOCITRATE SYNTHASE; 1.
DR   PANTHER; PTHR42880:SF1; ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000196526};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          56..326
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   458 AA;  52398 MW;  42AAF8E46792FC10 CRC64;
     MFGYSKKSNL LENTQQDFSL IDVKDPNLYR DFFPYDEVPK VVFNHRVVPM NVPENIWITD
     TTFRDGQQSR EPYTVNQMTH LFDLIHKLSG PKGIIRMSEF FLYTRKDQEA VYKCLEKGYE
     FPEVTSWIRA SKKDFELVKE IGLKETGILV SCSDYHIFHK MHMTRHQALD HYIAVVRECI
     ETGVIPRCHF EDITRADFYG FVVPFASALM ELSRETGVPI KIRACDTLGY GVTYPGTMLP
     RSVQGIMYGL NNHAGVPSEY LEWHGHNDFY RAVNNATYAW LYGASGVNCS LLGIGERTGN
     TPLEAMIMEY AQLKGTLDGM DTTVITDIAE YYEKELGYNI PPMTPFVGKN FNVTRAGIHA
     DGLLKNEEIY NIFDTEKLLR RPVRIAISNT SGTSGIAHWI NSYFHLTGEA AVEKKDKVVE
     IVYNWVNEQY NDGRVTVITD GELERVTLDA MKEIDENK
//