ID A0A1Y4VBD6_9FIRM Unreviewed; 647 AA.
AC A0A1Y4VBD6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN ORFNames=B5E53_10655 {ECO:0000313|EMBL:OUQ66485.1};
OS Eubacterium sp. An11.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1965542 {ECO:0000313|EMBL:OUQ66485.1, ECO:0000313|Proteomes:UP000195664};
RN [1] {ECO:0000313|Proteomes:UP000195664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An11 {ECO:0000313|Proteomes:UP000195664};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ66485.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NFLV01000012; OUQ66485.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4VBD6; -.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000195664; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR46098; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR46098:SF1; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 647 AA; 70623 MW; 84D6FDA1B69D3451 CRC64;
MIHDKLTLGS LFDGSGGFPL GGLLSGITPV WASEIEPFPI RVTTKRLPFM KHYGDVSRMD
GAEVEPVDII TFGSPCQDMS IAGKRAGLGG SRSNLFYEAI RIVKEMRCAT DGKYPRYIVW
ENVPGAFSSN KGADFQSVLE EVCSVKGYEI HTPRPERWAN AGEIMADDFS LAWRVFDAQY
WGVPQRRKRI YLVADFAGGS AGKILFESEG VSGYTPQGFR PWQGTAGTFA EGAGASGCVC
LNDQGGSRMD VTEDVAATLR AENHGHPPCV MGAAGFCTEH SAQARGIGYE EETSPTLRTG
TVPAAVYENH SQDTRYTGPL ETAPTVMSTY GTGGNNQPFV VETPKTLKIR SGCEGGGKGA
LIQDNKSATL GCNNDQTVFV PFVKGTRPHS PDEEPQWKAS DVANTLNTCD VGETRCNELA
VKVYGICSKD SNAMKSENPK SGFYEAETSR CLDANGGNPT CNQGGMAVVA LQGSMIGRAE
KNGPQGSGVN EDVSFTLDAA DRHAVAYCMT TGTYTQMLKE QSPTLMARDY KDPPVVNETE
PEYIVRRLMP TECARLQGFP DWWCTGLETD EPSEEEIEFW TEVFEIHRSV MGKSSRPKSR
NQIIKWLKNP HSDSAEYKMW GNGVALPNVY FVLSGIVYYS QFPEFLL
//