ID A0A1Y4WFC4_9FIRM Unreviewed; 763 AA.
AC A0A1Y4WFC4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:OUQ80233.1};
GN ORFNames=B5E43_04715 {ECO:0000313|EMBL:OUQ80233.1};
OS Flavonifractor sp. An100.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Flavonifractor.
OX NCBI_TaxID=1965538 {ECO:0000313|EMBL:OUQ80233.1, ECO:0000313|Proteomes:UP000196191};
RN [1] {ECO:0000313|Proteomes:UP000196191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An100 {ECO:0000313|Proteomes:UP000196191};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ80233.1}.
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DR EMBL; NFMA01000005; OUQ80233.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4WFC4; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000196191; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000196191};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 530..726
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 763 AA; 82569 MW; DBBDB4F5173D525D CRC64;
MRKLAIFACA CSAAVWAANF LLSQRILLPL GILCLLAAIL VQFIPNRCRR LWMRLILCGG
ALGFLWTAVY IQIVLVPARA LDGQTVHLSA VVAEWPQETD YGYSVLVETE VSPLVSVSTL
LYVDEQGAGL RPGDEISTIT YCTLADRTLA GEAITYYTAK GIFLRGETYG ELNINRPDHI
PVRYWAAVFS KALKSGVDTV FPEDIAPMIR ALVTGNRENL TDSFTTSLQR TGLSHTVAVS
GMHLAFLAGM AVQLFGRSRR SAGAVCLLVL LFCGVAGNTP SVIRAAVMVW MLQLAPLVDR
ERDSFTSLAL ALLLLLLHNP FAAANIGLQL SFGAVAGILL VSDPIQVRLM ALFRLDHRPK
EKWKYWVIQV PRFLVSTFAS TMGASVLTIP LVAIHFRSVS LISPLANLLT LWAVAILFGV
GLLLGTLGIL LPGVSAVLAI PFTSLARYLD WVVELLGRLP MAAIPLDSFY YQAWVVYLCL
LIGCGLLLNK EGRWIIPACG GTVALCTAML FTLVAFRSGA MTAAVLDVGQ GQSVLLRTGD
YLALVDCGGD SMDNAGDIAA DYIQAAGRSS LDFLILTHYH EDHANGVSQL LQRMQVSQLI
LPDVEEESPL RQEIITLARE KGVPITFLRE DTRFHWGTSG ELTLLAPLGQ GTDTNELGLT
VLASAGNFDV LITGDMGGEV EHLLLEHTEL PDLELLVAGH HGSATSTTQE LLQAVTPDMT
AISVGEHNLY GHPAQETLER LAQSGTEIYR TDLQGTILVQ AKG
//
