ID   A0A1Y4WGZ2_9FIRM        Unreviewed;       292 AA.
AC   A0A1Y4WGZ2;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:OUQ81361.1};
GN   ORFNames=B5E42_11880 {ECO:0000313|EMBL:OUQ81361.1};
OS   Flavonifractor sp. An10.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Flavonifractor.
OX   NCBI_TaxID=1965537 {ECO:0000313|EMBL:OUQ81361.1, ECO:0000313|Proteomes:UP000196537};
RN   [1] {ECO:0000313|Proteomes:UP000196537}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An10 {ECO:0000313|Proteomes:UP000196537};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ81361.1}.
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DR   EMBL; NFMB01000006; OUQ81361.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4WGZ2; -.
DR   OrthoDB; 9786703at2; -.
DR   Proteomes; UP000196537; Unassembled WGS sequence.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006398; Tartro_sem_red.
DR   NCBIfam; TIGR01505; tartro_sem_red; 1.
DR   PANTHER; PTHR43060:SF3; 2-HYDROXY-3-OXOPROPIONATE REDUCTASE; 1.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196537}.
FT   DOMAIN          2..159
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          163..283
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   292 AA;  30382 MW;  BEB7DC95D1492198 CRC64;
     MKIGLIGLGI MGKPMAKNLL KAGYDLTVSD LNKAAVDEVV AAGAKAATNA EIGETCDVVL
     TMVPNSPQVK AVMLGEDGVA AHMKPGSVFI DMSSINPVAS KEIAAELAKK GIEMLDAPVS
     GGEPKAIDGT LSFMVGGKQE VFDKYKDLLG AMGASVVRCG DVGAGNTTKL ANQIIVACNI
     QALSEALTLA KMAGVEPELV FQAIKGGLAG STVMNAKAPM MIEGNDKPGF KIDLHIKDLN
     NALDCAHTVG SPLPMTAAVQ EIFQWLHNNG CGQDDHSSII KYYKKLTGIE SL
//