ID   A0A1Y4WJE5_9FIRM        Unreviewed;       365 AA.
AC   A0A1Y4WJE5;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:OUQ81703.1};
GN   ORFNames=B5E43_02140 {ECO:0000313|EMBL:OUQ81703.1};
OS   Flavonifractor sp. An100.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Flavonifractor.
OX   NCBI_TaxID=1965538 {ECO:0000313|EMBL:OUQ81703.1, ECO:0000313|Proteomes:UP000196191};
RN   [1] {ECO:0000313|Proteomes:UP000196191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An100 {ECO:0000313|Proteomes:UP000196191};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUQ81703.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NFMA01000002; OUQ81703.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4WJE5; -.
DR   OrthoDB; 9808822at2; -.
DR   Proteomes; UP000196191; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13748:SF62; COBW DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR13748; COBW-RELATED; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196191}.
FT   DOMAIN          6..179
FT                   /note="CobW/HypB/UreG nucleotide-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02492"
FT   DOMAIN          277..362
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07683"
SQ   SEQUENCE   365 AA;  40727 MW;  529C6A86D7BAF953 CRC64;
     MTKIDIISGF LGAGKTTLIK KLLDEAFQGE KIVLIENEFG EIGIDGGFLK DAGVEITEMN
     SGCICCSLVG DFGAALKQVL ADYAPDRIII EPSGVGKLSD VIAAVERVQA ESPDLHLNSF
     VTVVDAVKAK VYMKNFGEFF NNQVEHACAI ILSRTQKLDP VKLDGAVHLL RAKNPKAAIL
     TTPWDQLTGK QIVSAMEGGH SLAEELMEEI QHSHHHEEHD EHCTCGCHDH EHHHDHDHDH
     HEHEHHHHDH EEGTCTACCD HDHHHHHHGH DADEVFTSWG RETPRKYSRE ELQEALSALA
     MGEDYGYILR AKGMVPCEDG QTWLHFDLVP GEFQIREGSA DYTGRLCVIG SELKEDRLEQ
     LFLLA
//