ID A0A1Y4WRB7_9FIRM Unreviewed; 461 AA.
AC A0A1Y4WRB7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Sodium:alanine symporter family protein {ECO:0000313|EMBL:OUQ84561.1};
GN ORFNames=B5E42_01710 {ECO:0000313|EMBL:OUQ84561.1};
OS Flavonifractor sp. An10.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Flavonifractor.
OX NCBI_TaxID=1965537 {ECO:0000313|EMBL:OUQ84561.1, ECO:0000313|Proteomes:UP000196537};
RN [1] {ECO:0000313|EMBL:OUQ84561.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=An10 {ECO:0000313|EMBL:OUQ84561.1};
RX PubMed=30064352;
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Whole genome sequencing and function prediction of 133 gut anaerobes
RT isolated from chicken caecum in pure cultures.";
RL BMC Genomics 19:0-561(2018).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC ECO:0000256|RuleBase:RU363064}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUQ84561.1}.
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DR EMBL; NFMB01000001; OUQ84561.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4WRB7; -.
DR OrthoDB; 9804874at2; -.
DR Proteomes; UP000196537; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR001463; Na/Ala_symport.
DR NCBIfam; TIGR00835; agcS; 1.
DR PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR Pfam; PF01235; Na_Ala_symp; 1.
DR PRINTS; PR00175; NAALASMPORT.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU363064};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW Reference proteome {ECO:0000313|Proteomes:UP000196537};
KW Symport {ECO:0000256|RuleBase:RU363064};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363064};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363064};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT TRANSMEM 14..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 65..87
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 93..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 237..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 306..325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 345..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 420..438
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
SQ SEQUENCE 461 AA; 48970 MW; 9F15B865DC76E42D CRC64;
MDAIVTFINW LDDFIWGIPM IVLLLGTHLF MTVRTGFIQR KLFTGIRLSV TKDPDSPGDV
SQFQALTTAL ASTIGTGNII GVGTAIFLGG PGAVFWCWIA GVFGIATKYA ESLIAVKYRV
RTRDGKMQGG AMYALERGLN LKWLGVAFAL LATIASFGIG CGTQINAIAE VIENNVPFHI
PPIAIGIVGG ILTAIVIIGG IQSIASVCEK LVPFMAIFYV LGCIIILGIN FDTLLPAIGA
ILRLAFTPGA VAGGLVGQGL LIALRFGVAR GLFSNESGMG SAPLVASAAQ TRNPVRQALV
SATGTFWDTV VVCLMTGLVL VTTIMKNPSI NMDSVTDGGQ LTTLAFSQIP VLGPIILVVG
IITFAWSTIL GWSYYGERCA QYLWGKKSLL PYKLIFVAVV VVGPVLALDL VWTIADILNA
LMAIPNLIAV LLLSGVIAKE TRHYLNNLDE VDKTEIPCVD K
//
