ID A0A1Y5EM96_9GAMM Unreviewed; 481 AA.
AC A0A1Y5EM96;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:OUR81747.1};
GN ORFNames=A9Q82_07930 {ECO:0000313|EMBL:OUR81747.1};
OS Cycloclasticus sp. 46_120_T64.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Cycloclasticus.
OX NCBI_TaxID=1856281 {ECO:0000313|EMBL:OUR81747.1, ECO:0000313|Proteomes:UP000195872};
RN [1] {ECO:0000313|Proteomes:UP000195872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hu P., Dubinsky E.A., Probst A.J., Wang J., Sieber C.M.K., Tom L.M.,
RA Gardinali P., Banfield J.F., Atlas R.M., Andersen G.L.;
RT "Simulation of Deepwater Horizon oil plume reveals substrate specialization
RT within a complex community of hydrocarbon-degraders.";
RL Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter
CC family. {ECO:0000256|ARBA:ARBA00025753}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUR81747.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MAAM01000011; OUR81747.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y5EM96; -.
DR Proteomes; UP000195872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR045016; NhaD-like.
DR NCBIfam; NF038006; NhaD_1; 1.
DR PANTHER; PTHR43269; SODIUM/PROTON ANTIPORTER 1-RELATED; 1.
DR PANTHER; PTHR43269:SF2; SODIUM_PROTON ANTIPORTER 1-RELATED; 1.
DR Pfam; PF03600; CitMHS; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..481
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012169989"
FT TRANSMEM 37..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..291
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
FT DOMAIN 344..426
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
SQ SEQUENCE 481 AA; 52497 MW; EE15C3133207B018 CRC64;
MNFISRFSCL LFLFLPTLAF SASTGEHTTL DLTDHTVGYL ALAVFVFAYT LVIFEEQLHL
RKSKPVLLAA GIIWIMIAIV YQQHGFDHAA EVAIRHNFLE YSELFFFLLV AMTYINAMIE
RGVFDALRGW LVKKGFSYKA LFWLLGILAF FISPVADNLT TALIMCTVAL TVGSKSPKFV
SISCVAIVVG ANAGGAFSPF GDITTLMVWQ KGIVQFTEFF ALFIPSVVNY LIPAAIMHFF
IPDGTPDAVE GEDLVMKRGG IMIVVLFLLT IVTAVSFHNF LHLPPAIGMM TGLAYLKFFG
YYLKRTYHLE ESATENPLTG EIAGEASEHG PHDSKGFDVF SKVAGAEWDT LFFFYGVIMA
VGGLGFIGYL GMVSETMYGQ LGPTYANIIV GVLSAIVDNI PVMFAVLTMQ PDMSHGQWLL
VTLTAGVGGS LLSVGSAAGV ALMGQARGIY TFASHLKWAP VIALGYAASI YTHLWVNAEL
F
//
