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Database: UniProt
Entry: A0A1Y5HD61_9RHOB
LinkDB: A0A1Y5HD61_9RHOB
Original site: A0A1Y5HD61_9RHOB 
ID   A0A1Y5HD61_9RHOB        Unreviewed;       421 AA.
AC   A0A1Y5HD61;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   31-JUL-2019, entry version 10.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=A9Q94_13645 {ECO:0000313|EMBL:OUS35191.1};
OS   Rhodobacterales bacterium 56_14_T64.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales.
OX   NCBI_TaxID=1856299 {ECO:0000313|EMBL:OUS35191.1, ECO:0000313|Proteomes:UP000195630};
RN   [1] {ECO:0000313|Proteomes:UP000195630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hu P., Dubinsky E.A., Probst A.J., Wang J., Sieber C.M.K., Tom L.M.,
RA   Gardinali P., Banfield J.F., Atlas R.M., Andersen G.L.;
RT   "Simulation of Deepwater Horizon oil plume reveals substrate
RT   specialization within a complex community of hydrocarbon-degraders.";
RL   Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OUS35191.1}.
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DR   EMBL; MAAY01000069; OUS35191.1; -; Genomic_DNA.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000195630; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000195630};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:OUS35191.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   DOMAIN      107    312       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   REGION      209    228       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   421 AA;  44137 MW;  E3DADC3A25EB57EE CRC64;
     MNILILGGGG REHALAWAVM QNPKCDKLIV APGNAGIAQI ATCADLDINH GGAVVTFAEE
     NAIDFVIVGP EAPLAAGVSN RLRDAGLLVF GPSEAAARLE VSKAFTKEIC AAVDAPTAGY
     GHFTEPQAAK AYIRQQGAPI VVKADGLAAG KGVIMAFDEA TALDAIDDMF GGAFGTAGAE
     VVIEEFMEGE EASLFVLVDG TDVLSMGSAQ DHKRVGEGDT GPNTGGMGAY SPAPVLTAEI
     EARAMNEIIK PTMQEMADRG APYQGILYAG LMIKDGQPRL VEYNVRFGDP ECQVLMMRLG
     AQALDLMQAA AEGRLDRAQV NWGDDHAICV VMAANGYPGV YDKGSEIKGL DAMSEDSSNM
     VFHAGTTAKD GKVLATGGRV LNVTARGDTL QEARDNAYTV ADAIDWPGGF MRRDIGWRAL
     K
//
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