ID A0A1Y5HKQ5_9RHOB Unreviewed; 1122 AA.
AC A0A1Y5HKQ5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=A9Q94_04295 {ECO:0000313|EMBL:OUS37829.1};
OS Rhodobacterales bacterium 56_14_T64.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales.
OX NCBI_TaxID=1856299 {ECO:0000313|EMBL:OUS37829.1, ECO:0000313|Proteomes:UP000195630};
RN [1] {ECO:0000313|Proteomes:UP000195630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hu P., Dubinsky E.A., Probst A.J., Wang J., Sieber C.M.K., Tom L.M.,
RA Gardinali P., Banfield J.F., Atlas R.M., Andersen G.L.;
RT "Simulation of Deepwater Horizon oil plume reveals substrate specialization
RT within a complex community of hydrocarbon-degraders.";
RL Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUS37829.1}.
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DR EMBL; MAAY01000026; OUS37829.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y5HKQ5; -.
DR Proteomes; UP000195630; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 8..480
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 506..785
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1122 AA; 123771 MW; 2DF9195E5C10662E CRC64;
MNSGQINRDA ASEAQFRAAR PDASTWLAAN AGSGKTKVLT DRVARLLLKG VQPQHILCLT
YTKAAASEMQ NRLFKRLGEW AMLQDTALIA ALTELGAEDV ISPEGLSQAR TLFARALETP
GGLKIQTIHS FCSSLLRRFP LEARVSPQFS EMEDRAASLL RAEISEDFAK GDQAHLVEAL
ARHVTDSDFD TLTAAISRRR AGFDTPLEWV DLLKLFDLPA DFDESALESL AFLGGEEELL
QRTRTMLASG GVNDQKAAQK LQGITRPTLS DLAALESVFL TGASAKEPFS AKLGSFPTKK
LREGHASLMD PLEPLMLRVE DARGKRLGLM TARKSHDLHQ FAAAFVPEYA RRKQLRGWLD
FDDLILKARQ LLNDPGVAAW VLYRLDGGID HILVDEAQDT SPVQWDVIEK LAQEFTSGEG
ARSDVERTIF VVGDIKQSIY SFQGADPDAF DRMRAEFGNR LRDTGTELQD ASLDFSFRSS
AAILGLVDLV FQDMPRAGFH KESLHRAFKG DLPGRVDLWP VVEKVDDKDE RDWTDPVDRP
GARHHNVILA ERIAQSIKQM IDDGVTIPED GSNRGTFIRR PVHAGDFLIL VQRRSDLFSE
IIRACKAARL PIAGADRLKV GAELAVKDLA ALLSFLATPE DSLSLACALK SPLFGWSEQM
LFDLAHRRSA KYLWTALRDR AEDFPETMQI LNDLRNQTDF LRPFDLIERT LTRHQGRKNL
LGRLGPEAED GINALLSQAL AYERTDIPSL TGFLVWMQTD DLEIKRQMGA AGSMIRVMSV
HGSKGLESPI VILPDTAKRQ PPRDDEIMMA DGTPMWKVPA AQMPATMLTA RELAQDKQRN
ERLRLLYVAL TRAEKWLIVA AAGDLAKDGD SWYQRVEFAL GDAGAVTLDT AGGPGLRLEH
GDWDGLPFEP REEKAQIKST LTTVFTTPAP PYAAPKPTLS PSDLGGAKAL PGEQGLDEDA
AMARGSQLHL LLEHLPSLPQ SDWPKIAQNL LQDATNCDEF LAEASAVIQN PDLSAIFAPD
TLAEVSVTSD LGDDRLHGII DRLLVTPDKI IAVDFKSNAT VPLTATQCPE GLLRQMGAYA
HALEQIYPDR QVETAILWTR TATLMPLPHD LVSAALMRRL IP
//
