ID A0A1Y5RDX2_9PROT Unreviewed; 883 AA.
AC A0A1Y5RDX2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN ORFNames=OCH7691_00307 {ECO:0000313|EMBL:SLN15256.1};
OS Oceanibacterium hippocampi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sneathiellales;
OC Sneathiellaceae; Oceanibacterium.
OX NCBI_TaxID=745714 {ECO:0000313|EMBL:SLN15256.1, ECO:0000313|Proteomes:UP000193200};
RN [1] {ECO:0000313|EMBL:SLN15256.1, ECO:0000313|Proteomes:UP000193200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7691 {ECO:0000313|EMBL:SLN15256.1,
RC ECO:0000313|Proteomes:UP000193200};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC Evidence={ECO:0000256|ARBA:ARBA00000783,
CC ECO:0000256|RuleBase:RU366031};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
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DR EMBL; FWFR01000001; SLN15256.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y5RDX2; -.
DR InParanoid; A0A1Y5RDX2; -.
DR OrthoDB; 7163809at2; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000193200; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR019133; MIC60.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF09731; Mitofilin; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW ECO:0000256|RuleBase:RU366031};
KW Reference proteome {ECO:0000313|Proteomes:UP000193200};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 422..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..230
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 282..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 624..675
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 326..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 90055 MW; 0FE6F0826AF15D64 CRC64;
MRLLITRPEP DASHLASALR KLNVQSLVEP MLTIHLDDSR RLEIGPGVQA VLVTSRNAAR
ALAVTCDRRD LKVYAVGDGT AQAARSAGFE TVASASGDLD ALVEKVVAEC DPSGGPLVHV
AGSVTTGDLK GRLEAAGFSC RREVLYSAEP VTSVSPRLEK ALVDREIDGV ILFSPRTAAA
FLALVEGAAL DDTLADLELF CLSEAVGKAA MPLLWREVHV AEQPNEEALL ALVARIDAAR
NGEASGSDTG RRPAKQAPEE EFIVALTAID TRPVDGAAEM MTNQSETDPD KEAAVAPAAA
AQSTGGQKAK DDPVAGSGKP ASPKPSGNGA GTTKAASTTT PAAAAKSTTG NGAPLPPRST
AASTGGSTPS TPPTPARTPT PASTSRPGSG SPSGGGTGGG NGGSGNAAGT ASPRRKRGGV
RWSLVVAVIA ILLVFASGMA VWPLLLPKLK AELSPEKLRL LGVESTGGAV AADPALMDRI
VSLENQVARG DSRAGQIGPR LDQLAGRLDT LEQNEGAASG AGGEQVAALA SRVDDLAATF
GALQGRLDDI DGRLRTLAGD AARIDDLEAN MAGLRETLDR AATSGGGADA AVIGELRQRI
DELAGRIDAG TGADADTDAL AAEIAELRQG ANGIENEIAA LGARVDRNAT LSGDLSSQAS
DIGALREKLS ALEQQTAERE AAGEKATADA QSRIERLEAA REARAGLDER MALALAINQL
SAATQGSSPF DQELAVASGL AGEALQPTLA ELVPHAAAGL PTLAELRASF DEEARQIVQA
ARELEDGDWL GHAMARIASV ITIRRVGEVE GVEADAVVAR AEVLLARGDL AGAVAELDGL
TGAAATAAAD WLGQARARLA LDTAIEQLHQ RVIAGLSGPK DGE
//
