ID   A0A1Y5SCY3_9RHOB        Unreviewed;       319 AA.
AC   A0A1Y5SCY3;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:SLN37547.1};
DE            EC=4.3.3.7 {ECO:0000313|EMBL:SLN37547.1};
GN   Name=dapA_2 {ECO:0000313|EMBL:SLN37547.1};
GN   ORFNames=PEL8287_01804 {ECO:0000313|EMBL:SLN37547.1};
OS   Roseovarius litorisediminis.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseovarius.
OX   NCBI_TaxID=1312363 {ECO:0000313|EMBL:SLN37547.1, ECO:0000313|Proteomes:UP000193827};
RN   [1] {ECO:0000313|EMBL:SLN37547.1, ECO:0000313|Proteomes:UP000193827}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8287 {ECO:0000313|EMBL:SLN37547.1,
RC   ECO:0000313|Proteomes:UP000193827};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
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DR   EMBL; FWFL01000004; SLN37547.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y5SCY3; -.
DR   OrthoDB; 6142028at2; -.
DR   Proteomes; UP000193827; Unassembled WGS sequence.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IEA:UniProtKB-EC.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193827}.
FT   ACT_SITE        136
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        164
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         209
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   319 AA;  34529 MW;  7F0889F5383F8DD8 CRC64;
     MSSNVFTGTM PALMTPCNAD RTPNFDLLVK KGKEMIAAGM SAVVYCGSMG DWPLLTDEQR
     MEGVARLTDA GLPVVVGTGA VNTKSAAAHA AHGQKVGAKG LMVIPRVLSR GSSPIAQKNH
     FKAVLSAAPD VPAVIYNSPH YGFSTRADLF FALRAEHSNL IGFKEFGGRD DLRYAAEHIT
     SQDDQVTLMV GVDTEVYHGF VNCGATGSIT GIGTALPKEA LLLAALSKKA AEGHAEARQR
     ALELSEAIHV LSTFDEGPDL ILYYKHLLVL NGEEEYTLHF NETDELTDAQ RNYCEQQYAL
     FRTWFADWSK QGGIIAECM
//