ID A0A1Y5TC32_9RHOB Unreviewed; 484 AA.
AC A0A1Y5TC32;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Cobyric acid synthase {ECO:0000256|ARBA:ARBA00019833, ECO:0000256|HAMAP-Rule:MF_00028};
GN Name=cobQ {ECO:0000256|HAMAP-Rule:MF_00028,
GN ECO:0000313|EMBL:SLN57046.1};
GN ORFNames=TRL7639_03080 {ECO:0000313|EMBL:SLN57046.1};
OS Falsiruegeria litorea R37.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Falsiruegeria.
OX NCBI_TaxID=1200284 {ECO:0000313|EMBL:SLN57046.1, ECO:0000313|Proteomes:UP000193077};
RN [1] {ECO:0000313|EMBL:SLN57046.1, ECO:0000313|Proteomes:UP000193077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7639 {ECO:0000313|EMBL:SLN57046.1,
RC ECO:0000313|Proteomes:UP000193077};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes amidations at positions B, D, E, and G on
CC adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine,
CC and one molecule of ATP is hydrogenolyzed for each amidation.
CC {ECO:0000256|ARBA:ARBA00025166, ECO:0000256|HAMAP-Rule:MF_00028}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953, ECO:0000256|HAMAP-Rule:MF_00028}.
CC -!- SIMILARITY: Belongs to the CobB/CobQ family. CobQ subfamily.
CC {ECO:0000256|ARBA:ARBA00006205, ECO:0000256|HAMAP-Rule:MF_00028}.
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DR EMBL; FWFO01000002; SLN57046.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y5TC32; -.
DR OrthoDB; 9808302at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000193077; Unassembled WGS sequence.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01750; GATase1_CobQ; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00028; CobQ; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002586; CobQ/CobB/MinD/ParA_Nub-bd_dom.
DR InterPro; IPR033949; CobQ_GATase1.
DR InterPro; IPR004459; CobQ_synth.
DR InterPro; IPR011698; GATase_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00313; cobQ; 1.
DR PANTHER; PTHR21343:SF1; COBYRIC ACID SYNTHASE; 1.
DR PANTHER; PTHR21343; DETHIOBIOTIN SYNTHETASE; 1.
DR Pfam; PF01656; CbiA; 1.
DR Pfam; PF07685; GATase_3; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51274; GATASE_COBBQ; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW Rule:MF_00028};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|HAMAP-Rule:MF_00028};
KW Reference proteome {ECO:0000313|Proteomes:UP000193077}.
FT DOMAIN 5..237
FT /note="CobQ/CobB/MinD/ParA nucleotide binding"
FT /evidence="ECO:0000259|Pfam:PF01656"
FT DOMAIN 249..432
FT /note="CobB/CobQ-like glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF07685"
FT ACT_SITE 329
FT /note="Nucleophile"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00028"
FT ACT_SITE 426
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00028"
SQ SEQUENCE 484 AA; 51655 MW; 94AC766A3894E617 CRC64;
MVQAIMIQGT GSNVGKSMLV AGLTRAFSRR GLRVAPFKPQ NMSNNAAVAV GGEIGRAQAL
QARAAGLEPH TDMNPILLKP ETDTGAQIIV QGQRRGTMQA GDYRKGKAQL LAAALESFHR
LCADADLVLL EGAGSPAETN LRAGDIANMG FACAAGVPVV LVGDIHRGGV IAQIVGTQAV
LDDTDLAQIS GFAVNRFKGD VTLFDEGRDD IAARTGWPCL GVVPWFNDAW KLPAEDMMDI
RSHLGGACKI VVPQLERMAN FDDLDPLSGE PNVSVEIIPA GRPLPGDADL VLLPGSKSTI
GDLNYFRAQG WDIDLYAHVR RGGHVVGLCG GYQMLGKTIA DPEGIEGFIG EVEGLGLLDV
HTTMAGQKKV TQTQATDIHT GLPVYGYEIH IGRTEGPDCD RPWLQVGERS EGAISPSGRV
RGSYLHGTFA SDSYRAAFLQ ELGHRSDLSY EESVEATLDD LADHLERHMD LDLLLQLARA
PKGL
//