ID   A0A1Y6D4I3_9GAMM        Unreviewed;      1027 AA.
AC   A0A1Y6D4I3;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Multidrug efflux pump {ECO:0000313|EMBL:SMF97506.1};
GN   ORFNames=SAMN02949497_0536 {ECO:0000313|EMBL:SMF97506.1};
OS   Methylomagnum ishizawai.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylomagnum.
OX   NCBI_TaxID=1760988 {ECO:0000313|EMBL:SMF97506.1, ECO:0000313|Proteomes:UP000192923};
RN   [1] {ECO:0000313|EMBL:SMF97506.1, ECO:0000313|Proteomes:UP000192923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=175 {ECO:0000313|EMBL:SMF97506.1,
RC   ECO:0000313|Proteomes:UP000192923};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FXAM01000002; SMF97506.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y6D4I3; -.
DR   STRING; 1760988.SAMN02949497_0536; -.
DR   OrthoDB; 9758297at2; -.
DR   Proteomes; UP000192923; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF14; BLL4319 PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192923};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        333..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        529..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        848..867
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        874..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        907..929
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        950..971
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        977..1005
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1027 AA;  110440 MW;  1DB029C6DAAC3D38 CRC64;
     MRFTDLFIQR PVLAIVVNLL LFILGVRAVA TLPIAQYPET ESAVITVVTG YFGADPSLVA
     GFISTPMEAA ITQANGIDYI TSTSVSGIST ITVNLQFGYK VDKALTEISA KVNSILGQLP
     PDSQHPIISV QPSQSFDALY IGFSSDILPS NNVTDYLVRV VQPKLQAVAG VQTAELIGAK
     YFALRAWLDP EKLAAYGLTA TDIQLALAQN DYLAALGSTK GQMVQVNLAA STSLHSVDEF
     RELIVKHEGD HLVRLKEVAT VSLGAEDYDS QAGFDGQKAV YIGIKVAPSA NLLDVVQRVK
     AEFPAIKAQL PNGIDGDIVY DSTVFVTSSI REVVETLVEA LFIVTLVVFL FLGSPRSVLI
     TIIAIPLSLV ATFGVMLMLG YSINLLTLLA LVLAIGLVVD DAIIVVENVN RHLAEGLSPV
     AAARRAAREL ASPIVAMTAV LAAVYMPIGF QTGLTGTLFT EFAFTLVGAV TFSALVALTL
     SPMLCSRLLR SAEGDGGWEA RLVGRIDRVL DGCQAGYARK LRGSLDYRPV TFVFAGIILV
     AIYFLYTNAN SELAPQEDQG ILFALGMASP TATQQQRQLY ANQVLDVFKR YPETEHVLQM
     DMAGQTIEGM VLKPWDQRKR NSTQLMMEIQ QEVGEIAGMF VAAFQPPSLP SSGSLPVQFV
     IGTTEPAEQL DAVAKEFMEA AQQSGMFLYL DNDLKFNHPQ VWVDIDRDKA ALLGLSMQDI
     GGSLTSMLGG GYVNYFSMAG RSYKVIPQVD RSFRLNADQL EGYYIRNAQG AAVPVSTVVR
     LRTETIPQSV NHFQQLNAAT ISGIAFPSLS QGEVLDYMRD LAGRLLPPGY SVDYAGQSRQ
     FVQEAGNFIT TFGFALLVIF LVLAAQFESF RDPLIILISV PMSIVGALVF VSLGLGGGSL
     NIYTEVGLVT LMGLISKHGI LIVEFANGLQ EQGLSKREAI ETAAGIRLRP ILMTTAAMVF
     GVLPLLFASG AGAASRFSIG MVIVLGLTVG TLFTLFVVPA VYMLLAKQHT GPAPEEEVSD
     LAASHTH
//