ID A0A1Y6D4I7_9GAMM Unreviewed; 1159 AA.
AC A0A1Y6D4I7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Natural product biosynthesis luciferase-like monooxygenase domain-containing protein {ECO:0000313|EMBL:SMF97501.1};
GN ORFNames=SAMN02949497_0531 {ECO:0000313|EMBL:SMF97501.1};
OS Methylomagnum ishizawai.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomagnum.
OX NCBI_TaxID=1760988 {ECO:0000313|EMBL:SMF97501.1, ECO:0000313|Proteomes:UP000192923};
RN [1] {ECO:0000313|EMBL:SMF97501.1, ECO:0000313|Proteomes:UP000192923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=175 {ECO:0000313|EMBL:SMF97501.1,
RC ECO:0000313|Proteomes:UP000192923};
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; FXAM01000002; SMF97501.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y6D4I7; -.
DR STRING; 1760988.SAMN02949497_0531; -.
DR OrthoDB; 7903015at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000192923; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.20.20.30; Luciferase-like domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR024011; Biosynth_lucif-like_mOase_dom.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR011251; Luciferase-like_dom.
DR InterPro; IPR036661; Luciferase-like_sf.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020803; PKS_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04020; seco_metab_LLM; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00296; Bac_luciferase; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00828; PKS_MT; 1.
DR SUPFAM; SSF51679; Bacterial luciferase-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Monooxygenase {ECO:0000313|EMBL:SMF97501.1};
KW Oxidoreductase {ECO:0000313|EMBL:SMF97501.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192923};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 408..823
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 1159 AA; 122087 MW; A886138CD079C7BF CRC64;
MNPSVETADV LTREILELLA ATAPESGRLS PAEFAARHQA RPQPRKTLDF SIMFFSAAAD
AVPAAGLYDL LRRAAVSADR LGFAAIWLPE RHFHRFGGAY PAPAVLAAVL ADLTRRVRLR
AGSITLPLDS PIRVAEAWAM VDQLSGGRVD LGFGNGWSPN DFVLAPECFA ERKGILRERI
EQVRGLWRGE ALSFINGEGG RVPVRTWPRP VQAEPPIWIA ATGNPETFAW AGAQGFNILT
MLLGGTLQDT AGRVRVYREA RRAAGLDPAG GRVALMLHTL VHPDRARVMA AVQEPFTRYV
RDALDAQRHA SPEGRALDET QREQMVRYAT ERYTRTAALF GPPEDCQALL REIAGADIDE
IACLIDFGPE TDLVLEALPH LAGLRDQWNG VPACHPAPEP AAIATPNHSP IAIIGMSGSF
PGAPDLAALA EALAANTSAL RPPPPGRYGA ETPALALGGF IDEVEWFDPT PFRLSPAEAA
VMDPHQRLLL SAARRCFADA GLSPAAVAGT ATGVFLALYS DSHSARQPTP PNGQPDPLAA
TGRIHALAAN RISHVFDLAG PSEVVATACS SGLVAVHRAV QAVRAGECAM ALVAAASLLL
SDGESRALGG LGILSPEGRC RPFDRAANGQ ARGEGVCALL LKPLDAALAA GDPIHAVIRG
SATNHSGAAS GSLLLPNANR QADCMAQALA DADVPLAGLG YIEAHGAGGA GDLAELAAFA
EVWRRQGAVP HEPGIALASG KAAMGSLDAA GGLAGLARAV LAVREGMLPG LAAGGDLGAD
SPLAGTPFYL NRQPRPWTGP ETRRAGVHAY GLGGVNAHVI VEAPPRPRPA ASPPPPEQPL
HFPLPPETCG SVPVPAPASV VGDFYDYVTR DDHGRFEETY LTLAPFPEPV PGFSWTRTMQ
NPAAHPDHAR LLLDKQREMR AVAFAPVDFA QARRMLDIGC GLGTDLIVLA ETHPQLEGVG
YTLSPAQAGA AGQRIAAWGL ERRLTVRQGD SARDAFPGRF DLIFGFEVAH HIRDKDGLFA
NIAGALAPDG VLVLADTVAG TVAPVDLAAV GSYTLPRGDY ARLFARHGLE IVDCVDLSQE
IANFLVDPQL EAMLAAEADT ARQLGRDHGF PLAEAVQRSW DAFGAALREG LMLYVLIHAR
PALPGGPTLA ANLRMMEAA
//
