ID   A0A1Y6DBM7_9GAMM        Unreviewed;      1016 AA.
AC   A0A1Y6DBM7;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SMF97025.1};
GN   ORFNames=SAMN02949497_4441 {ECO:0000313|EMBL:SMF97025.1};
OS   Methylomagnum ishizawai.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylomagnum.
OX   NCBI_TaxID=1760988 {ECO:0000313|EMBL:SMF97025.1, ECO:0000313|Proteomes:UP000192923};
RN   [1] {ECO:0000313|EMBL:SMF97025.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=175 {ECO:0000313|EMBL:SMF97025.1};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR   EMBL; FXAM01000001; SMF97025.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y6DBM7; -.
DR   STRING; 1760988.SAMN02949497_4441; -.
DR   Proteomes; UP000192923; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF68; PROBALE CATION EFFLUX SYSTEM PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192923};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        333..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        437..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        470..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        517..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        858..877
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        884..902
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        914..935
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        956..975
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        987..1010
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1016 AA;  109946 MW;  ED1EE9B646F8641F CRC64;
     MMARLIQFAL TQRVFALLLA LLLAGAGWLA AMNLPIDAFP DVSPTQVKII VKVPGMTPEE
     VEARVTAPVE VELLGIPKQT MLRSIAKYAL TDITLDFEEG TDIYWARQQV AERLNAAWAN
     LPANAEGGMA PMTTPLGEMF MFTVEGEGLS LADRRSLLDW VIRPALRTVP GVADVNTLGG
     RVRSFEVIPD NMRMAARGVS IGELTTALKA NNRNDGAGRL VQGEESLLVR AEGRIVDLDD
     VRTIVIVQRN GIPITVGDVA EVRIGALTRY GAVSQDGKGE AVEGLVLSLR GANARQVVAG
     LEQKLEEIQP ALPKGVKIDV FYNRAHLVEK ATYTIIHALV EATVLVLVLL LAFLGDVRAA
     LTVACILPMV ALFTFLLMHQ FGLTANLMSL GGLAIAIGKL VDPAVVVVEN ITAHLAEHSK
     AQRLPRLHII YRAMREITAP VVSGAMIIGI VFVPLFSLEG LEGKLFKPVA FTNVFAMSGS
     LIFSLIVIPV LASFLMTKVK HEEPWLARQF LALYRPVLLW SLAHGRTVMA GAGLLLLSTL
     FVYNQIGKTF MPTMDEGDII VQVEKLPSIT LEESVRLDQQ IQKAIMEHVP EVVRAVSRVG
     VDEIGLDPMG LNETDNFFVL KPQAEWRMKT KEELTEAIRK VLDTIPGIAY GFTQPIQMRV
     TEMLTGVRGD VAVKLYGPEL SVLNAKAEEI AAAMKKIPGA SDVFTVRNEG MQYLVVKLDR
     LAAGRLGLDA DALADTLRAQ IEGLKLGIVQ EDIRRTPLLL RGSGEPAHMA TLQIALPDGR
     RVPLSAVAKI EPVEGVVAVN RERGQRYASV RSNVEGRDLV GFVEDAKRAV AAQVQLPTGY
     YIQWGGQFEN QQRAADRLAV VIPLSIGLIF LLLFSTFGSV RQAGLVLANV PLALIGGVYG
     VWISGEYLSV SASVGFISLL GIAVLNGVVM VSYFNQLRAL GLPMDEVVVT GALRRLRPVL
     MTAGIAAFGL IPLLFATGPG SEIQRPLAVV GVGGLCTSTL LTLVMLPVLY RRWGEA
//