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Database: UniProt
Entry: A0A1Y6EKV9_9RHIZ
LinkDB: A0A1Y6EKV9_9RHIZ
Original site: A0A1Y6EKV9_9RHIZ 
ID   A0A1Y6EKV9_9RHIZ        Unreviewed;       502 AA.
AC   A0A1Y6EKV9;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=SAMN06295905_0789 {ECO:0000313|EMBL:SMQ63274.1};
OS   Devosia lucknowensis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Hyphomicrobiaceae; Devosia.
OX   NCBI_TaxID=1096929 {ECO:0000313|EMBL:SMQ63274.1, ECO:0000313|Proteomes:UP000194474};
RN   [1] {ECO:0000313|EMBL:SMQ63274.1, ECO:0000313|Proteomes:UP000194474}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L15 {ECO:0000313|EMBL:SMQ63274.1};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FXWK01000001; SMQ63274.1; -; Genomic_DNA.
DR   BioCyc; GCF_900177655:CCK88_RS03890-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000194474; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000194474};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000194474};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      415    498       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   502 AA;  53440 MW;  77F324F05C03C3E1 CRC64;
     MSDIQSFRQS VETFISARGW TPTRFGRIVA GDPLFVFDLR DGREPRTETR ARILKAMAEL
     GDADRQAPLR VGVAGLGNVG ATLVRILQKD GAELTRKLGR QLEVVAVAAR SRSRDRGIDI
     SGLEWFDDPV ALAKWDGIDL FVELIGGEDG PAFAAVKAAL EIGRPVVTAN KALLAKHGVT
     LARMAEESGA QLGFEAAVAG GIPVIKTLRE GLGSARIAKV FGIMNGTCNY ILTRMGNEGI
     SFADCLKDAQ ALGYAEADPT FDVEGFDTAH KLSILATLCF GYEIAPDKMR IEGISGITQH
     DIQVAHDLGY KIKLLGIAER TEHGIEQRVH PTFVPKGSAI AGVDGVMNAV ALETDHVHEL
     LLAGPGAGGP PTASSVLSDI LDIARGTRVP PLGVPSDELL PYREAPHRAH EGGFYIRLSA
     KDVPGALAAI TTRMGEKSIS IDSVIQRSDL SAKAVAPDGS PTRTVVMITQ QTLESSVREA
     LAEIAADGFI VGQPQLIRIE KL
//
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