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Database: UniProt
Entry: A0A1Y6HHH9_9XANT
LinkDB: A0A1Y6HHH9_9XANT
Original site: A0A1Y6HHH9_9XANT 
ID   A0A1Y6HHH9_9XANT        Unreviewed;       375 AA.
AC   A0A1Y6HHH9;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Prephenate dehydrogenase {ECO:0000256|ARBA:ARBA00016891};
DE            EC=1.3.1.12 {ECO:0000256|ARBA:ARBA00012068};
GN   Name=tyrA {ECO:0000313|EMBL:SMR02969.1};
GN   ORFNames=PD5205_01665 {ECO:0000313|EMBL:SMR02969.1};
OS   Xanthomonas fragariae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=48664 {ECO:0000313|EMBL:SMR02969.1, ECO:0000313|Proteomes:UP000195953};
RN   [1] {ECO:0000313|EMBL:SMR02969.1, ECO:0000313|Proteomes:UP000195953}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PD5205 {ECO:0000313|EMBL:SMR02969.1};
RA   Song R., Chenine A.L., Ruprecht R.M.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC         NADH; Xref=Rhea:RHEA:13869, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC         ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001162};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC       hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005067}.
CC   -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007964}.
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DR   EMBL; LT853885; SMR02969.1; -; Genomic_DNA.
DR   RefSeq; WP_002804366.1; NZ_ORZZ01000094.1.
DR   AlphaFoldDB; A0A1Y6HHH9; -.
DR   STRING; 48664.BER92_07985; -.
DR   GeneID; 61894077; -.
DR   KEGG; xfr:BER92_07985; -.
DR   eggNOG; COG0077; Bacteria.
DR   eggNOG; COG0287; Bacteria.
DR   OrthoDB; 5939631at2; -.
DR   UniPathway; UPA00122; UER00961.
DR   Proteomes; UP000195953; Chromosome 1.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:SMR02969.1};
KW   Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498}.
FT   DOMAIN          5..277
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   375 AA;  41179 MW;  A6D4E0232BB029C8 CRC64;
     MMAQPVVGIV GIAGAYGRWL AQFLRTHMQL EVIGFDPTDG GGMDEATLAQ RADVLIFSAP
     IRHTATLIER YVELAGPRAA SQLWMDVTSI KQAPVAAMLA SQAEVVGLHP MTAPPKSPTL
     KGRMMVVCEA RLRHWSEWVQ TLCAALQAEC VYATPEHHDR VMALVQAMVH ATHLVQAGTL
     RDYAPLLGEL RALMPYRSAS FELDNAVIAR ILSLNPSIYE DIQFGNPYVG EMLDQMLLQL
     QQLRALVAQG DDAARAQFRS QFLDDNAQAL QRESLTAGNY TYERVGYLLA DLTEPLALSV
     YLPEDQPGSL RALLHVFEQH GVNLSSIHSS RTPAGELHFR IGFESKSNRA AVAKAANEID
     RSGIGRVLER SGQVD
//
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