ID A0A1Y6ISC7_9VIBR Unreviewed; 377 AA.
AC A0A1Y6ISC7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Multidrug resistance protein MexA {ECO:0000313|EMBL:SMR99700.1};
GN Name=mexA {ECO:0000313|EMBL:SMR99700.1};
GN ORFNames=VIM7927_00928 {ECO:0000313|EMBL:SMR99700.1};
OS Vibrio mangrovi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=474394 {ECO:0000313|EMBL:SMR99700.1, ECO:0000313|Proteomes:UP000196125};
RN [1] {ECO:0000313|EMBL:SMR99700.1, ECO:0000313|Proteomes:UP000196125}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7927 {ECO:0000313|EMBL:SMR99700.1,
RC ECO:0000313|Proteomes:UP000196125};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; FXXI01000001; SMR99700.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y6ISC7; -.
DR OrthoDB; 9806939at2; -.
DR Proteomes; UP000196125; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF29; BLR2860 PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..282
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 153..180
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 377 AA; 40956 MW; EC8719ADC7647BC3 CRC64;
MSKNYLQPTS LQRTRGRTIF SLLMTAIVLM LIFGGLFYWK QQNQAQAQGW HPQAIPVTAM
ELKSQELPVT MDAVGSLTAV QEVTLSAEVA GRVSAINFKS GAQVETGSLL VQLFDGPEQA
DRMAAIAKAK FAKHQYLRSK DLVPAGAESL DLLQQRESTH EQAEANIKQL EARLRQKQIR
APFSGELGIR QINLGQYLNP GEAVVTLTSL DPLYVEFTLP QQVLSDLKIG AKVQVHSDAY
PDRIFSAQVN AIEPQIDQDT RNIIIQATLP NPDRDLRPGM YVTASLSLAP QPDAILVPST
AVQTSAQGYS AVVIRGDDAA SQGKAEIVSV RLGRRVGNQL VVTDGLKQGD IVVTEGQNRV
MPGAELQVAH LAGAEEM
//
