ID A0A1Y6ITA4_9VIBR Unreviewed; 690 AA.
AC A0A1Y6ITA4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=helD_1 {ECO:0000313|EMBL:SMS00858.1};
GN ORFNames=VIM7927_02129 {ECO:0000313|EMBL:SMS00858.1};
OS Vibrio mangrovi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=474394 {ECO:0000313|EMBL:SMS00858.1, ECO:0000313|Proteomes:UP000196125};
RN [1] {ECO:0000313|EMBL:SMS00858.1, ECO:0000313|Proteomes:UP000196125}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7927 {ECO:0000313|EMBL:SMS00858.1,
RC ECO:0000313|Proteomes:UP000196125};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FXXI01000003; SMS00858.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y6ITA4; -.
DR OrthoDB; 5298826at2; -.
DR Proteomes; UP000196125; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR022161; Helicase_IV_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12462; Helicase_IV_N; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 198..511
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 219..226
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 690 AA; 79684 MW; 03B0B9A6C8339336 CRC64;
MQLKASNTAK YFINDEFYHV AIDGEKLIVR STVAEERIPF AIWDGSIRVR RGILWGELEF
FAHIHDGQRY SWLIRGLPWP QCRTFAEKAI AAYRQWHQLQ CVKLSTYLPS WQQALIRLQN
ESAFLPHSEV REWHQQVSRD LTELGMTLDE IEQRVPGVIA DTAAWYHQPS LMLSQRNETW
ITSERERWTT LFNTLESSPL NVSQQSAVLL NDNYNLVLAG AGSGKTSVLS ARVAYLIESG
LSEAGQILLL SFGKDAALEM EQRLRERVGP AADQVTVSTF HQLGLRIIHE VEGQDVQLSP
IVSETKQKEA WMTDWLKKHW MTPTNFKRWQ KHLNQWPIAY IKGDEELGSH VENPKLISWL
TRQVEQLSLL SLSKKEIQQK IVEREDYPRL NSELALCWPC YQAWNEMLKE QGQLDFNLMI
SQATTYVRKK KYQSRWAFVM VDEYQDISPP RLALLEALCK QHEPRGNLFA VGDDWQSIYQ
FAGSDVDLTT GFQQRFPEST VTHLDTTYRF NNRLGEVANT FVQVNPQQIP KSLNSLKVQK
SNAVALLPQS RLEKIIEQLN RKNAAKDQVK SLLILGRNHY HKPELLEAWQ KQYRQLDIRF
MTCHASKGKE ADFVIIVHVD EGQFPAKTKT VHLDDVLTLS DETFPHAEER RLFYVAMTRA
REKVWVAYNA GGGSSFVKEL LEGPYSVSKL
//
