ID A0A1Y6K3B5_9CHLR Unreviewed; 734 AA.
AC A0A1Y6K3B5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Putative penicillin-binding protein {ECO:0000313|EMBL:SMX53358.1};
GN ORFNames=CFX1CAM_0292 {ECO:0000313|EMBL:SMX53358.1};
OS Brevefilum fermentans.
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Brevefilum.
OX NCBI_TaxID=1986204 {ECO:0000313|EMBL:SMX53358.1, ECO:0000313|Proteomes:UP000195514};
RN [1] {ECO:0000313|Proteomes:UP000195514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kirkegaard R., Mcilroy J S.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; LT859958; SMX53358.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y6K3B5; -.
DR KEGG; abat:CFX1CAM_0292; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000195514; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000195514};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..734
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013300540"
FT DOMAIN 54..162
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 173..338
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 373..695
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 734 AA; 79778 MW; 888772CA1ED8C587 CRC64;
MKVRARFLLI FACLVLVATT LMAGCLGMGG DWTGQPIWSG KGDVTSAATV QHVLEGFLTD
WAVEDYPAMY ARLTRLSRDA ITLEEFTRIY ENFAQTLTLE SIQTQVLSTL AEANHAEAAY
RVAYYTRLFG ILSRDTVATL TREPDGWRIQ WETGMLLPDL RGGNRLDFVS QLPSRGRIFD
RSGAPLAAYE NALAIGVVPG EILPEQAPDL FAALAEISIY SSDSLGRLVE STPDDWYLPV
VSLSQAAAVP YLEHLQSFYG VRISEFRSRF YLDGGVAPHA LGYMLYIPEE LLDDYLRRGY
RQDERIGAYG LEAAFEAELA GVHGGSVYVK STSGQIVSLL ATSEPSPGLS ITTTLDKTLQ
THLQTSLGNL RAAVVVIEVD SGRVLALVSN PHFNPNAFDL TEIDHSMLES YFSDPAQPLF
NRATQGQYPL GSIFKVISMS AALESGLYRP DSRFFCGQSM WVCNSVTLYD WTINYGLASG
DLSLVEGLMR SCNPWFYRIG ESLYNNDQDG FLSEMAYSFG LGALTGIEIA EAPGNIPPVA
GSCLNSAQIS IGQGEVLVTP LQVAAFFAAL ANGGTLYRPA LVESLSTVTG EKTYTFTPDL
QGELPISEKT LAALAEGLRM VVEEQRGTAY GTLQGLEIPV SGKTGTAETP SGTSHAWFAG
YTRVNDPDRP DIAVVVLLEN AGEGSVMAAP VFRRAVTLYF SDGEDPGGIM PWESEPYVLY
QPEPEPADES TTGE
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