ID A0A1Y6K9B5_9CHLR Unreviewed; 1044 AA.
AC A0A1Y6K9B5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Putative serine hydroxymethyltransferase/aminomethyltransferase {ECO:0000313|EMBL:SMX54620.1};
GN Name=glyA {ECO:0000313|EMBL:SMX54620.1};
GN Synonyms=gcvT {ECO:0000313|EMBL:SMX54620.1};
GN ORFNames=CFX1CAM_1555 {ECO:0000313|EMBL:SMX54620.1};
OS Brevefilum fermentans.
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Brevefilum.
OX NCBI_TaxID=1986204 {ECO:0000313|EMBL:SMX54620.1, ECO:0000313|Proteomes:UP000195514};
RN [1] {ECO:0000313|Proteomes:UP000195514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kirkegaard R., Mcilroy J S.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
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DR EMBL; LT859958; SMX54620.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y6K9B5; -.
DR KEGG; abat:CFX1CAM_1555; -.
DR OrthoDB; 9803846at2; -.
DR Proteomes; UP000195514; Chromosome i.
DR GO; GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR006223; GCS_T.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR039429; SHMT-like_dom.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR NCBIfam; TIGR00528; gcvT; 1.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF00464; SHMT; 2.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:SMX54620.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000195514};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SMX54620.1}.
FT DOMAIN 10..83
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT DOMAIN 87..425
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT DOMAIN 643..921
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
SQ SEQUENCE 1044 AA; 116425 MW; DBB84D05A65A8066 CRC64;
MRQFHHQKDL ENIDPGLYEI IKLEEERQVR RLIMIPSESA TPVAVRESLG SIFTNIYAEG
YPPPETQKYT EEEILDYTHM LGMYRRYGDP RFYKGVEYVD VVEALARHRC AKVFATNNLT
PDDLYVNVQP LSGAPANNAV YSAFLQPGDT ILGMNLLHGG HLTHGSSVNR SGMIYNAQHY
SVDPVTEKLD YDAILEKALE VKPKIIIAGY SSYPWMPDWQ KFREIADSAG ALLLTDVSHI
AGLIAAGVVP SPVGFAHIIT FTTHKSMLGP RGACIITDNP DFSKKIDKSI FPGEQGGPHI
NTIASMALAF KLAQTDAFKR LQAQVLKNAV AFADQLQKRG MRVPYQGTNT HLVLLDCKTV
KAKDGTHLSG EMGARILDIA GIVANYNTIP GDRSTFSASG IRFGTHWLTQ RGLEPEDFAQ
IADIICDLFC AVTPYKMPGR TRTLQHAKVD FNILEDAKRR VIALAEKADP LIDLPKYHGY
PHFFSLDDNI DAEWARFSLS GDQIRMFLDY TLVSEIENLD EGESQATMIH TSEGSIKGVI
KCLDPGTFTL YVPGHQAGLT SSWLRNLSDG YIKFDDDLML TVPGPVRVED LPPGAPDITI
KILSSNRKPY YIGMDNDEHT GEILPEFVWE EPQSEELRRT PLFQTHVNMG ARMIPFAGWE
MPVWYTSVME EHKAVRQTAG LFDVTHMGVY QAEGPDAAIF LDSVCGNDIS WLAVGESCYT
HFMDLDANVI DDLLVYRRDK QKFLVVVNAS NDDKDWAWLN AVRKGEVLVD RGKPWAVAFG
RNVILRDLRD PQAGEDMLVD IAIQGPKSRD ILLSLNCSLV DREAILELSR SHLCEATLDG
IPIVVSRTGY TGEQIGYELF VHPDRSVELW NKLIQIGQPY GMKPCGLGAR DSLRTEAGLP
LYGHEMGGEL NLGTSEAGFS WFVKRHKPWF IGRTAFLERE TKREGNIVRF RFDEKRTRLA
HLGDPVVDER GKVVGTVTSC AIDTEGSLTG QAYVLDKYTK EDTPILIYQS TPSSGGKALG
QLQTGDRVTL PSRATVISRY PKRS
//