ID A0A1Y7VL88_MOUSE Unreviewed; 183 AA.
AC A0A1Y7VL88;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=NADP+ dependent oxidoreductase domain containing 1 {ECO:0000313|Ensembl:ENSMUSP00000152360.2};
DE Flags: Fragment;
GN Name=Noxred1 {ECO:0000313|Ensembl:ENSMUSP00000152360.2,
GN ECO:0000313|MGI:MGI:1918525};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000152360.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000152360.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000152360.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000152360.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000152360.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000256|ARBA:ARBA00005525}.
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DR AlphaFoldDB; A0A1Y7VL88; -.
DR SMR; A0A1Y7VL88; -.
DR ProteomicsDB; 326171; -.
DR Antibodypedia; 54657; 30 antibodies from 13 providers.
DR Ensembl; ENSMUST00000221768.2; ENSMUSP00000152360.2; ENSMUSG00000072919.5.
DR AGR; MGI:1918525; -.
DR MGI; MGI:1918525; Noxred1.
DR VEuPathDB; HostDB:ENSMUSG00000072919; -.
DR GeneTree; ENSGT00950000183044; -.
DR OMA; CIVYSFV; -.
DR Proteomes; UP000000589; Chromosome 12.
DR Bgee; ENSMUSG00000072919; Expressed in seminiferous tubule of testis and 68 other cell types or tissues.
DR ExpressionAtlas; A0A1Y7VL88; baseline and differential.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR PANTHER; PTHR11645:SF58; NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR11645; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 80..165
FT /note="Pyrroline-5-carboxylate reductase catalytic N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03807"
FT NON_TER 183
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000152360.2"
SQ SEQUENCE 183 AA; 20641 MW; 2278B59028FCB2A1 CRC64;
MEMLEDLESL RFEFGIPEEE RYWLYLQGRY RGLMIKGCAH AAFFCKMFST LSNLLQNLPR
TIHPRTVSFD NAATEDELLT VGIIGCGHLG KQLTNVLLKT VPIPAENLQI STRRPESLGE
LRKLGVRCVY DNAAVASWAK VLFLCCLPAQ LPNICLEIQS KLNKHCTVYS FVSAIPLPRL
KSL
//
