ID A0A1Y9HBI2_ANOFN Unreviewed; 611 AA.
AC A0A1Y9HBI2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=PA domain-containing protein {ECO:0000259|Pfam:PF02225};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN002670-PB, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN002670-PB}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN002670-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A1Y9HBI2; -.
DR STRING; 62324.A0A1Y9HBI2; -.
DR EnsemblMetazoa; AFUN002670-RB; AFUN002670-PB; AFUN002670.
DR VEuPathDB; VectorBase:AFUN002670; -.
DR VEuPathDB; VectorBase:AFUN2_003470; -.
DR OrthoDB; 5474929at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd02122; PA_GRAIL_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR Pfam; PF02225; PA; 1.
DR SUPFAM; SSF52025; PA domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..611
FT /note="PA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013096990"
FT TRANSMEM 231..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..198
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT REGION 287..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 68144 MW; AAE2E4C8AC1FD223 CRC64;
MMSALSHQVN MNNFLSLLVG ASLVAANSSP SHDIASLSQP TEFSNGVSSF ALPAEERMAI
ESFVMAYLNY SYTGSDGHLV ELGGNESAKY GEGRVLNRSG ILVHISNSVN RSDHTGCYKH
WSGTLGESIP DRSTPWIALV RRGGCNFEDK VKHAYEHGAA GVIIYNDKGD SKLDKMKIND
KERNITAVFT SKAMGLELIE ILEVHKYDVH MRIIEGSHQF HPLGNINRTS VLFVSISFIV
LMIISLVWLV FYYVQRFRYL QTKDKQSFTG SQESILQLDM DMEEGDLIDD RSSTDGGYQR
RNSVSPLPQI RASNENQMSR SSSDSDSEQD HEDCVTPQSS GRRSSQGRNK RDSQRQHEKS
QQDGDICVGC LAAALNKKQK NNDNAQEDGE SDSYATEENG SKSLPATLKK YKGNHSTGSC
RGMNPPDHYH PYPYNDKHGS RVYQNQQPQN SAPEEHSSQQ SSNLPFKFYK TESGQPRKVR
TPLRNLIPQS ISAPCDTDSS LRVCIHGGIE QHFSEATTSK TGTLHANVES EELPAVHISQ
RPIDAKRRCS LSRNSSCSSA DRKDVVTCED LKIAIDYSNE EDVSDETEPN SDNDLIIRRS
ERGDEKETRK K
//
