ID A0A1Z1FBC9_9SPHN Unreviewed; 678 AA.
AC A0A1Z1FBC9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ARU16075.1};
GN ORFNames=A9D14_07560 {ECO:0000313|EMBL:ARU16075.1};
OS Croceicoccus marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Croceicoccus.
OX NCBI_TaxID=450378 {ECO:0000313|EMBL:ARU16075.1, ECO:0000313|Proteomes:UP000195807};
RN [1] {ECO:0000313|EMBL:ARU16075.1, ECO:0000313|Proteomes:UP000195807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E4A9 {ECO:0000313|EMBL:ARU16075.1,
RC ECO:0000313|Proteomes:UP000195807};
RA Wu Y.-H., Cheng H., Xu L., Huo Y.-Y., Wang C.-S., Xu X.-W.;
RT "Complete genome sequence of esterase-producing bacterium Croceicoccus
RT marinus E4A9.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
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DR EMBL; CP019602; ARU16075.1; -; Genomic_DNA.
DR RefSeq; WP_066844797.1; NZ_CP019602.1.
DR AlphaFoldDB; A0A1Z1FBC9; -.
DR STRING; 450378.GCA_001661675_01514; -.
DR KEGG; cman:A9D14_07560; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000195807; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000195807}.
FT DOMAIN 299..474
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 479..535
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 678 AA; 72051 MW; 6F3F86692E763918 CRC64;
MGETVTVSVD NGIAIVTIAN PPVNALGRAV RQDLDAAADR IASDGDIRAA IIRADGGTFP
AGADIAEFPD VPAPLHGDVF DKIEALHKPV VAAIHGTALG GGLELALACH FRVAAEGAKM
GLPEVQLGLL PGARGTQRLP RLIGAEAALG MMLTGKPIDA AKALKAGLID ELVPATELDD
KAFEMATALM AKDGPLPRAS QDSEWTRKDR DDPQLFDRVK DAHGRLFRGV IAPDAILTCV
KAAVELPFDK GAEVEASEFA RLLSSDQSRA LIHVFFAMRE TAKVPGIGRE TPLIDIKSVG
IIGAGTMGGG IAMCFANAGI PVKLVEVKAE ALERGLGVIR KNYENTAKKG RLTDDQVESL
MNSIAGTLDM EDLSDVDLVI EAVFESMEIK EKVFTRLDSI AKQGAILASN TSFLDINHIA
AMTSRPEMVL GLHFFSPANV MPLLEVVRGD KSSDSVIATG MKLGKTLRKT PVLAGVCDGF
IANRLMFPYM VASQQMLLRG TPMQDIDAAM KQYGFAMGPI ALLDLIGLDV IDFPGEITMT
GELVKAERRG QKLNGGFYDY DEKRRGTPAP AALEIIEKVR AAHGIETAPP LQADEILTGL
LYPVVNEGAR ILEEGIALRA GDIDVTAILG YNWPSYQGGP MCWADIHGLD RIVSGLEKMD
VQPAPLLAEK AASGGSFT
//
