ID A0A1Z2KVP7_9ACTN Unreviewed; 672 AA.
AC A0A1Z2KVP7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NERD nuclease {ECO:0000313|EMBL:ARZ66086.1};
GN ORFNames=SMD11_0420 {ECO:0000313|EMBL:ARZ66086.1};
OS Streptomyces albireticuli.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1940 {ECO:0000313|EMBL:ARZ66086.1, ECO:0000313|Proteomes:UP000195755};
RN [1] {ECO:0000313|EMBL:ARZ66086.1, ECO:0000313|Proteomes:UP000195755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MDJK11 {ECO:0000313|EMBL:ARZ66086.1,
RC ECO:0000313|Proteomes:UP000195755};
RA Wang Y., Du B., Ding Y., Liu H., Hou Q., Liu K., Yao L., Wang C.;
RT "Streptomyces albireticuli Genome sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP021744; ARZ66086.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z2KVP7; -.
DR KEGG; salj:SMD11_0420; -.
DR Proteomes; UP000195755; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR011528; NERD.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF08378; NERD; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50965; NERD; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 17..116
FT /note="NERD"
FT /evidence="ECO:0000259|PROSITE:PS50965"
FT DOMAIN 221..525
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 242..249
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 672 AA; 73969 MW; D1A5A9CC1F918EC0 CRC64;
MREQLKAAQW DVRNWEAASE GERKVAAKLH VLTRRGWRLL LDRRWPGTRA ANVDMLLVGP
GGVFVIDVKN WRHAPEAVDG HLTAGGRTYD REIGKLLKVT RLAENAVSAR NLSPVAVQPL
MVFAGRSLDA ALGTVRLLGE REVTPALIAE RTRLRPSEVK AVADHLERTF PAYEDTSART
GPAAPASPVP APDDALFDVE GIRNAAVEAA RSAPIEQWMT FLHPDQLALV RRDWSGPARV
SGPAGTGKTV VALHRAAHLA RRTSGRILYV TFANNLPRVQ GTFLKAMAPA VADRIDFRSL
HAWAGQFLRD RGVATRLDHD KSVDAFSRAW QSHGRRTVLE TLDPAPGYWQ EEIDYVIKGR
GITSFEQYAP PLRRERRRTV LRRTHREAVW ALYQEYERNR TAKGVHDFND ILALALAEAL
AHPGATPYTS VIVDEVQDLT FVGVRLLHAL VGDAANGLLL VGDGQQAVYP GGFRLSDAGI
DVRGRGQVLR ANYRNAKEIL DAALAVVADD AFDDIDGTPT AGRRDVDLTY GDGGRVTRCT
APTRTEHDEA LLAALRALGP EAWPDSAVLC RTGAERERYR RLLTRAGIPA VTLEQYDGRP
VPGVKLGSYH RAKGLEFKHV HLPDHDAPAT AAPGDGTDDG VARERRELHR SQLFVAMTRA
RDTLWLGSFG RP
//
