ID   A0A1Z2LBR4_9ACTN        Unreviewed;      2796 AA.
AC   A0A1Z2LBR4;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Putative nonribosomal peptide synthetase {ECO:0000313|EMBL:ARZ71658.1};
GN   ORFNames=SMD11_6082 {ECO:0000313|EMBL:ARZ71658.1};
OS   Streptomyces albireticuli.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1940 {ECO:0000313|EMBL:ARZ71658.1, ECO:0000313|Proteomes:UP000195755};
RN   [1] {ECO:0000313|EMBL:ARZ71658.1, ECO:0000313|Proteomes:UP000195755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MDJK11 {ECO:0000313|EMBL:ARZ71658.1,
RC   ECO:0000313|Proteomes:UP000195755};
RA   Wang Y., Du B., Ding Y., Liu H., Hou Q., Liu K., Yao L., Wang C.;
RT   "Streptomyces albireticuli Genome sequencing and assembly.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP021744; ARZ71658.1; -; Genomic_DNA.
DR   KEGG; salj:SMD11_6082; -.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000195755; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd19540; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 4.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 3.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 5.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          979..1054
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2446..2521
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          2746..2786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2763..2783
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2796 AA;  295695 MW;  6F086B8364A19BC0 CRC64;
     MIPLSFAQQR LWFLHKLEGP GATYNLPFAL RLTGELDTDA LEAALRDVVG RHESLRTVFP
     ETAGVPRQVV LDPVEAWPGM KVVPVPEDAL AAETEAAARY AFDLSCEPPL RSTLLRLSER
     QHVLVVTLHR IAGDGWSLGP LARDLSTAYA ARRAGGAPDW AELPLRYTDY TLWQRELLGA
     EDDPDGLPAR QGAYWRQALD GAPEELALPH DRPRPAVASY RGGHVSFALG PELHAGLRRL
     AREHGTTLFL VLQAGLAAML SRTGAGEDIP VGFDVTGRPD EALDDLVGLF ANTLVLRTDV
     SGDPTFTELL GRVRERAQEA YGHQDVPYAH LVAALAPAPS AARHPLFQVA LLLRHQQAEF
     AFPGLRARPE WPGTGTSRFD LSFSLAERLG ADGAPAGLDG TLEYAAELFD HPTAVALAGR
     LTRVLEQAVA APGTPVGGLE VLSARERHDV LEGWNDTVRE GGVGDVVECV RELAEARPGH
     VAVVDGSGEV SYAALAARAA GVTARLRELP EWERGRVVGL LAGPGTGFVA GVLGVLGAAG
     AFVPLDPAAP DGRSGGVVAD GGVRVLLVEA GLEPLAARVV AASGAQVSVL PLRAAADEDP
     ARTWEVAPAS PLDLAYVIFT SGSTGRPKGA MVHRGGMANH LSAKVADLRL TAEDSVVQNA
     PLTFDVAVWQ MLAPLAIGGR ARVVDHATAA DPEALFGVVA DEDITVLEVV PSLLRTALDA
     WDAGLRAPDL PDLRWLMVTG EELPPELCDR WFARYPDVPV VNAYGPTECS DDVAHAVLTG
     PVTGARTPIG KPVRNTRFYV LDERLRPVPV GVPGELYVAG RGVGRGYVAD PVRTAAVFVA
     DPYAPAPGER MYRTGDQVRW RADGQLEFLG RRDFQIKVRG HRVELGEIEA ALRGAPGVTD
     AAASLVHDPA GRPQLCGYVT GATDPAAVRA HLTGLLPGYM VPAVVTVLPA LPLTTHGKTD
     RKALPAPDLT AVTATASRPP RTLAEEMLCG LFAEILGLDT VGADDSFFDL GGHSLLATRL
     ASRVRTAFGA ELPVRDVFEA PTPAGLATRL DTAAAARPAL ARRPRPEPVP LSYAQRRLWF
     LHKLEGPGAT YNMPVAVRLS GELDVPALEA ALRDVIGRHE SLRTVFPETA GVPRQLVLDP
     AGAWPGLTAV PVAEDGLEAE IAAAARHGFD LSCEPPVRTT LLRVSEREHV LLCVLHHVAG
     DGWSLGPLTR DLSEAYRARR AGHGPGWAEL PVQYADYTLW QRELLGAEDD PDSVMSRQVA
     YWRDELAGAP EELALPYDRP RPAVASHRGG YVPFEVGPEL HEGLHRLARE HGATPSMVLQ
     AGLAALLSRL GAGEDVPVGF GVAGRLDDAL DGLVGFFVNT LVLRADLSGD PTFTELLGRV
     RRSALAAYAH QDVPFEHLVE TLAPERSAAR HPLFQVALVL QNNRRAEIDL PGLRTRMEWA
     GTGTSRLDLF FSLDEREDAA GRPAGLDGVV EYATELFDRA TVEGLAARLL RVLEQAVADP
     GAPVGLLDPL SARERHDVLD GWNDTAVEPA GPATLPGLFE ARAARTPEAV AVDHGGEETA
     YAELDARAGL LARRLAAAGV GPGDLVALAL PRSAGLVAAV LGVLKAGAAY LPVDPGYPDA
     RIRFMLSDAA PKLLLTDGPT AKALPGTGVE HWLLDDPATA AAPEAPVRPP RPDDPAYVIY
     TSGSTGRPKG VVVPHKGLPA LAAAQAANLA VDGTSRVLQL ASPSFDASVW DLLMALAAGG
     TLVLPGTEGP LAGEALAGTL AERRVTHLTI TPSALEAVPA GAESTLGTLR TVVTAGETCP
     APLVARWAPG RLMVNAYGPT EATVCATMSG ALSAEAVGTG PVPIGRPIAD ARVYVLDARL
     RPVPPGVTGD LYLAGPGLAH GYLNRPGLTA GRFVACPFGA PGERMYRTGD VAAWTPGGQL
     VFRGRADEQV KVRGHRVELG EVEARLLEHP SVGRAAVVAR EETPGDVRLV AYVVPATGAG
     AADGGLVDEW RDIHDQVYAA SGPAPWGEDF RGWDSTYDGE PIPVEQMREW RDATVARIAE
     LRPRRVLEIG VGAGLLLSRL AGHCETYWGT DFSPAAVARL TAHVAADPEL AGKTELRCRP
     ADDVDGLPAD FFDTIVINSV AQYFPDAGYL SEVLGKCLGL LAPGGALYVG DVRNLRTRRA
     LQAGVAGHRP ADDASGRADA LDLAVDAEPE LLVAPEFFTA LAAADDRVTG VDIRLKRGLH
     HNELTRHRYE AVLRKTSGTA GPAAETVPLP VDGLEELPWE RLATGGSGAD GVAALAARLA
     TGGTGLRITG VPNGRVLAEF SALAALGRPG DVPATPVQGP GADPEALCRL GEALGLRPVA
     TWSPARHDTF DIAFLPAGTT GPVAAYSHPE ADPDPAAHVS TPLRARHRDP ATAVPDLKRH
     LAELLPAFMV PAAYVTLDDL PVTVNGKLDR KALPEPAPAA APAGRAARTP VEELLRGAFA
     DVLGLASVGT DDSFFDLGGH SLLATRLVSR IRTALGAELT LRDLFGAPTV AELAGLVAAR
     RTEARPAPRP YERPERVPLS PAQDRIVRIG LGEGAASSAL KNMPVALRLV GDTDRAALEA
     ALTDVVHRHE ALRTLFPGPD GDRYQRVLPP EDARVTLPVV TTTEAGLADL VRDAAHHAFD
     LRTEPPFRAA LFRVSENEHV LVLVWHHIAG DGWSVGVLLG DLAAAYAARR AGTGPRREPL
     ALQYADYTLW LRELLGDASD PESLAARGHA FWNEALAGLP AEVTLPWTGR GRSAPPTGAR
     PSPSRSPRRS TAASRSWPPS RTPPCSWCCT RPWPPP
//