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Database: UniProt
Entry: A0A1Z2TKD4_9EURY
LinkDB: A0A1Z2TKD4_9EURY
Original site: A0A1Z2TKD4_9EURY 
ID   A0A1Z2TKD4_9EURY        Unreviewed;       333 AA.
AC   A0A1Z2TKD4;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   16-JAN-2019, entry version 6.
DE   SubName: Full=Homoserine dehydrogenase {ECO:0000313|EMBL:ASA76899.1};
DE            EC=1.1.1.3 {ECO:0000313|EMBL:ASA76899.1};
GN   ORFNames=CDI07_00830 {ECO:0000313|EMBL:ASA76899.1};
OS   Thermococcus sp. 5-4.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=2008440 {ECO:0000313|EMBL:ASA76899.1, ECO:0000313|Proteomes:UP000196843};
RN   [1] {ECO:0000313|Proteomes:UP000196843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5-4 {ECO:0000313|Proteomes:UP000196843};
RA   Cossu M., Badel C., Catchpole R., Daniele G., Marguet E., Barbe V.,
RA   Forterre P., Oberto J.;
RT   "Flipping Chromosomes in Deep-Sea Archaea.";
RL   PLoS Genet. 0:0-0(2017).
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DR   EMBL; CP021848; ASA76899.1; -; Genomic_DNA.
DR   KEGG; thh:CDI07_00830; -.
DR   KO; K00003; -.
DR   Proteomes; UP000196843; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000196843};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2};
KW   Oxidoreductase {ECO:0000313|EMBL:ASA76899.1}.
FT   DOMAIN       10    143       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      156    327       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      10     15       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    223    223       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     100    100       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     124    124       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     208    208       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   333 AA;  36441 MW;  7018604A6321A31F CRC64;
     MREVRLSLFG FGNVGRALAR VLIEKGSIFR ERYGLEFKVV SIADTSAVVW LPEGVDLREA
     LMVKENFGRL SSWTNDYEVY SFTPEEAVRE IDADVVIDVT NDKNAHTWHL AALKDGKAVV
     TSNKPPLAFH YAELMREAEM RDLPYLFEAT VMAGTPIITL LRDGLKGDTV ERIEAVLNAT
     TTFILSRMES GLDFEGALKE AQELGIAERD PSGDVLGIDA GYKATILHCL AFHPVTFNDA
     HVKGIAEVTP EDVNRAMERG RTLRLVATVE DGKVRVEPRE VPLDGPLAVE SHENAAVIKT
     DLLDELVIKG AGAGLKETAS GVVSDIIKAA LNL
//
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