ID A0A1Z2TPR5_9EURY Unreviewed; 354 AA.
AC A0A1Z2TPR5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA repair and recombination protein RadA {ECO:0000256|ARBA:ARBA00018144, ECO:0000256|HAMAP-Rule:MF_00348};
GN Name=radA {ECO:0000256|HAMAP-Rule:MF_00348,
GN ECO:0000313|EMBL:ASA78436.1};
GN ORFNames=CDI07_09050 {ECO:0000313|EMBL:ASA78436.1};
OS Thermococcus sp. 5-4.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=2008440 {ECO:0000313|EMBL:ASA78436.1, ECO:0000313|Proteomes:UP000196843};
RN [1] {ECO:0000313|EMBL:ASA78436.1, ECO:0000313|Proteomes:UP000196843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-4 {ECO:0000313|EMBL:ASA78436.1,
RC ECO:0000313|Proteomes:UP000196843};
RX PubMed=28628615; DOI=10.1371/journal.pgen.1006847;
RA Cossu M., Badel C., Catchpole R., Daniele G., Marguet E., Barbe V.,
RA Forterre P., Oberto J.;
RT "Flipping chromosomes in deep-sea archaea.";
RL PLoS Genet. 13:e1006847-e1006847(2017).
RN [2] {ECO:0000313|Proteomes:UP000196843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-4 {ECO:0000313|Proteomes:UP000196843};
RA Cossu M., Badel C., Catchpole R., Daniele G., Marguet E., Barbe V.,
RA Forterre P., Oberto J.;
RT "Flipping Chromosomes in Deep-Sea Archaea.";
RL PLoS Genet. 0:0-0(2017).
CC -!- FUNCTION: Involved in DNA repair and in homologous recombination. Binds
CC and assemble on single-stranded DNA to form a nucleoprotein filament.
CC Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand
CC exchange between homologous DNA molecules. {ECO:0000256|HAMAP-
CC Rule:MF_00348, ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family.
CC {ECO:0000256|ARBA:ARBA00008050, ECO:0000256|HAMAP-Rule:MF_00348,
CC ECO:0000256|PIRNR:PIRNR005856}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP021848; ASA78436.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z2TPR5; -.
DR KEGG; thh:CDI07_09050; -.
DR OrthoDB; 31129at2157; -.
DR Proteomes; UP000196843; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd19515; archRadA; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00348; RadA_arch; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR011938; DNA_recomb/repair_RadA.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR NCBIfam; TIGR02236; recomb_radA; 1.
DR PANTHER; PTHR22942:SF39; DNA REPAIR PROTEIN RAD51 HOMOLOG 1; 1.
DR PANTHER; PTHR22942; RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF08423; Rad51; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00348};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00348,
KW ECO:0000256|PIRNR:PIRNR005856};
KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_00348,
KW ECO:0000256|PIRNR:PIRNR005856};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00348};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00348}.
FT DOMAIN 114..290
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
FT DOMAIN 295..354
FT /note="RecA family profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50163"
FT REGION 18..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 143..150
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00348"
SQ SEQUENCE 354 AA; 39261 MW; 4535D1E5F5178978 CRC64;
MPRKKKAEDE IKELEEFEEL DVVEESPSSS TKKKKEKEIK TLEDLPGVGP ATAEKLREAG
YDSIEAIAVA SPMELKEIAG ISEGAALKII QAAREAANIG TFMRADEYME KRRTIGRIST
GSKSLDKLVG GGVETQAITE VFGEFGSGKT QLAHTLAVMV QLPEEEGGLH GSVIWIDTEN
TFRPERIRQI AENRGLDPEE TLKNIYVARA FNSNHQMLLI EKAEEIIKEK AETDRPVKLL
VVDSLMAHFR SEYVGRGTLA ERQQKLAKHL SDLHRIADLY DIAVFVTNQV QAKPDAFFGD
PTRPVGGHIL AHSATLRIYL RKGKAGKRVA RLIDSPHLPE GEAIFRITDK GIED
//
