ID A0A1Z2TPR8_9EURY Unreviewed; 385 AA.
AC A0A1Z2TPR8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Tryptophan--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00140};
DE EC=6.1.1.2 {ECO:0000256|HAMAP-Rule:MF_00140};
DE AltName: Full=Tryptophanyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00140};
DE Short=TrpRS {ECO:0000256|HAMAP-Rule:MF_00140};
GN Name=trpS {ECO:0000256|HAMAP-Rule:MF_00140};
GN ORFNames=CDI07_09130 {ECO:0000313|EMBL:ASA78452.1};
OS Thermococcus sp. 5-4.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=2008440 {ECO:0000313|EMBL:ASA78452.1, ECO:0000313|Proteomes:UP000196843};
RN [1] {ECO:0000313|EMBL:ASA78452.1, ECO:0000313|Proteomes:UP000196843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-4 {ECO:0000313|EMBL:ASA78452.1,
RC ECO:0000313|Proteomes:UP000196843};
RX PubMed=28628615; DOI=10.1371/journal.pgen.1006847;
RA Cossu M., Badel C., Catchpole R., Daniele G., Marguet E., Barbe V.,
RA Forterre P., Oberto J.;
RT "Flipping chromosomes in deep-sea archaea.";
RL PLoS Genet. 13:e1006847-e1006847(2017).
RN [2] {ECO:0000313|Proteomes:UP000196843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-4 {ECO:0000313|Proteomes:UP000196843};
RA Cossu M., Badel C., Catchpole R., Daniele G., Marguet E., Barbe V.,
RA Forterre P., Oberto J.;
RT "Flipping Chromosomes in Deep-Sea Archaea.";
RL PLoS Genet. 0:0-0(2017).
CC -!- FUNCTION: Catalyzes the attachment of tryptophan to tRNA(Trp).
CC {ECO:0000256|HAMAP-Rule:MF_00140}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-
CC tryptophanyl-tRNA(Trp); Xref=Rhea:RHEA:24080, Rhea:RHEA-COMP:9671,
CC Rhea:RHEA-COMP:9705, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57912, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78535, ChEBI:CHEBI:456215; EC=6.1.1.2;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00140};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00140}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|HAMAP-Rule:MF_00140,
CC ECO:0000256|RuleBase:RU363036}.
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DR EMBL; CP021848; ASA78452.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z2TPR8; -.
DR KEGG; thh:CDI07_09130; -.
DR OrthoDB; 371821at2157; -.
DR Proteomes; UP000196843; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004830; F:tryptophan-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00806; TrpRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR HAMAP; MF_00140_A; Trp_tRNA_synth_A; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR002306; Trp-tRNA-ligase.
DR InterPro; IPR020653; Tryptophan-tRNA-ligase_arc.
DR NCBIfam; TIGR00233; trpS; 1.
DR PANTHER; PTHR10055:SF1; TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10055; TRYPTOPHANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01039; TRNASYNTHTRP.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|HAMAP-Rule:MF_00140};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00140}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00140};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00140};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00140};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00140}.
FT COILED 336..367
FT /evidence="ECO:0000256|SAM:Coils"
FT MOTIF 82..90
FT /note="'HIGH' region"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00140"
FT MOTIF 253..257
FT /note="'KMSKS' region"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00140"
SQ SEQUENCE 385 AA; 44865 MW; D589CEDEF0F4A119 CRC64;
MDDAFKVTPW DVEGMVDYAK LIEEFGTSPL TDELLEKTAR LTRSELPIYF RRRFFFSHRD
YDKVLADYEN GKGFFLYTGR GPSGPMHIGH IIPFFATKWL QEKFGVNLYV QITDDEKFLF
KEKLTFDDTK RWAYDNILDI IAVGFDPDKT FIFQDSEFTK IYEMAIPIAK KINYSMAKAV
FGFTDQSKIG MIFYPAIQAA PTFFERKRCL IPAAIDQDPY WRLQRDFAES LGYYKTAAIH
SKFVPGLMGL EGKMSASKPE TAVYLTDDPE EAGKKIWKYA LTGGRATAKE QREKGGEPEK
CVVFKWFEIF FEPDDKKLME RYHACKSGEL LCGQCKRELI ERVQAFLKEH QKKRKEAEKK
VEKFKYTGEL AREQWDKSIP EPLKN
//