ID A0A1Z4BYZ5_9GAMM Unreviewed; 1137 AA.
AC A0A1Z4BYZ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:ASF46527.1};
GN ORFNames=CEK71_10840 {ECO:0000313|EMBL:ASF46527.1};
OS Methylovulum psychrotolerans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylovulum.
OX NCBI_TaxID=1704499 {ECO:0000313|EMBL:ASF46527.1, ECO:0000313|Proteomes:UP000197019};
RN [1] {ECO:0000313|EMBL:ASF46527.1, ECO:0000313|Proteomes:UP000197019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HV10_M2 {ECO:0000313|EMBL:ASF46527.1,
RC ECO:0000313|Proteomes:UP000197019};
RA Mateos-Rivera A.;
RT "Genome Sequencing of the methanotroph Methylovulum psychrotolerants str.
RT HV10-M2 isolated from a high-altitude environment.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP022129; ASF46527.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z4BYZ5; -.
DR KEGG; mpsy:CEK71_10840; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000197019; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000197019};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1137
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012193390"
FT TRANSMEM 514..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 823..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..936
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 942..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..289
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 520..856
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 917..958
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 960..1025
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 1033..1116
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 175..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..165
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1137 AA; 128599 MW; D1E44D4383207298 CRC64;
MKQTDKRRPY FYAQWPLLTV LLILGIGAVQ AANTQTGQNP PVSASTALQA KIDAVTARQD
FDETTKTSVL KFYHSAQDNL ANIELFNSKT ESFKQATKQA PEAIKKLQKD LEQIQQKQAK
QKPESFTDIA TDELEQRLII EKEKLSNLDE QLKNLDTELT LQNSRPPLIR QETLTAQQDL
DNSQKKSASP ATSTTLKIES EAEQLYLKTL IDARTAELKM LDIEAISNPV RVDLLKAQYQ
LLDSQRSMEA PILTAIDSIL AERRLQAAKE AQDALSQAEK DLAGKHLVIQ MLTRENIQFS
KDLQATTSKT DAYNEQEAKL DSQVTEIDND FKSAEKKISL AGLSPALGKI LREQRRNLLI
DIQQGLQSES VQNETALTSL ELFKVEDKLQ KLADVDHELQ QIMSAQVDPH MPNEQRMMIQ
AELRVLLNNQ KELLNKVMVA DDTYLRSLGD FDFARQQMVA QATKYAAFLD ERLLWVPSSE
PINADFLPGL YHAGQWLLSP MNWAEVIKDT LKSLYYHAFA AVLAIASLLV LVFSQHWNKT
HLLAIAEQVG KFYSDHFLYT VKALLHLLLL ILPLPLLLFY WGWFLSHTWN INEFSKVVGT
GFQVSAVPMF FLQFFYRLFA PQGIARKHFQ WQAETASLFR RQIAWLRFIA VPSVFLINST
GASGVALYSD NIGRLALVLS MVAMAAFFRN ILHPTRGLLQ YVIAAAPQGW LHQSRYFWYP
GAISLPLIII GFAVAGYYLS ALELQQQLII TLRLVFVLVV IHSLVFRWLT LVNRQLAIAN
DQQRRKLAAQ PEKPHIVGAE DVVVPIEEPL IDIPKINAQT IKLLNVFICV ALLIGIWLIW
KNILPAFSFL DHIQLWEYQV TEGKQDTMKP VTLTNLLLAG VYVFITVVSV VNFSGLMEIV
WFRRLSVEPG SRYAINKLAK YLLISIGFLC VANELGGSWT QVQWLVAALS VGLGFGLQEI
FANLVSGIIL LFERPIRVGD TVTIGDVTGR VSRIQMRATT IMDWDQKELV VPNKTFITNQ
LVNWTLSDSI TRVVIPIGIA YGTDLEKAHQ LMLETVQNTP MVLTDPEPVV VLTGFGDSSL
MFSIRVFVSE MAHRLQVVHN LHLRLDRALR EHNIEIPFPQ REVHVRETVT TQETPPK
//
