ID A0A1Z4BZZ5_9GAMM Unreviewed; 651 AA.
AC A0A1Z4BZZ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Adenylate/guanylate cyclase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CEK71_12645 {ECO:0000313|EMBL:ASF46856.1};
OS Methylovulum psychrotolerans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylovulum.
OX NCBI_TaxID=1704499 {ECO:0000313|EMBL:ASF46856.1, ECO:0000313|Proteomes:UP000197019};
RN [1] {ECO:0000313|EMBL:ASF46856.1, ECO:0000313|Proteomes:UP000197019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HV10_M2 {ECO:0000313|EMBL:ASF46856.1,
RC ECO:0000313|Proteomes:UP000197019};
RA Mateos-Rivera A.;
RT "Genome Sequencing of the methanotroph Methylovulum psychrotolerants str.
RT HV10-M2 isolated from a high-altitude environment.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; CP022129; ASF46856.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z4BZZ5; -.
DR KEGG; mpsy:CEK71_12645; -.
DR OrthoDB; 9806704at2; -.
DR Proteomes; UP000197019; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029150; dCache_3.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF14827; dCache_3; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000197019};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 313..365
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 397..529
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 651 AA; 71843 MW; 0988B05762E56E29 CRC64;
MSGRSACRRN SALILATVKR FRHFTRFRSR LLFYIIGLLL LVLAGVFAVV NHIFRQNTEE
TIRHELVVTE RVFLRLLSER SQDLSQQATA LASDYAFKRV IATQDHDTIT SALINLSARA
QADAAFLVAL DHTVKIDTLR PEQAGQAFFS PALLEQAESE GMASRLMLVG RKPYQVIVVP
ILAPEPIAWL CLGFLVDNPV LAQLKQLTQV EISLLSEHGQ TLQVHATTLP APTPQQLPLY
PVQSDGFFWH TGQERYLSRL VTLEQQADGK LVALIERPWS KALENFYRLQ WLLLVIALFS
IGLASLAAAW LAKSVSKPVQ ILAQGVQAIG QGDYRHQVQI DSTDEIGQLG LAFNSMGTQL
LEKEKIRTLL GKVVSPVVAQ ELLNHELVLG GETREITALF TDLAGFTNIS EQLSPQDLVA
LLNGYLTEMS AAISAHAGVL DKFIGDAIVA FWGAPVTDTA HAQQAVACAL AMQRILQDLR
EDWQRRGLPL LFMRVGINTG PAVVGNIGSI DRLDYTMIGD TVNLAARLEG ANKYYGSGIL
ISEFTYQHVS SLFACRELDK VRVQGKQQPV AVYEVIAEHK QLSVRQRQLC SGFAEALAAF
RGQQFQQAQV MFGALVEQYQ DAASALYLRR IAELVSDGGR VGFDGVYDLA K
//
