ID A0A1Z4EET8_9MYCO Unreviewed; 400 AA.
AC A0A1Z4EET8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:BAX91473.1};
DE EC=1.1.1.284 {ECO:0000313|EMBL:BAX91473.1};
GN ORFNames=B2J96_05405 {ECO:0000313|EMBL:PRI16239.1}, MSG_01315
GN {ECO:0000313|EMBL:BAX91473.1};
OS Mycobacterium shigaense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=722731 {ECO:0000313|EMBL:BAX91473.1, ECO:0000313|Proteomes:UP000217736};
RN [1] {ECO:0000313|EMBL:PRI16239.1, ECO:0000313|Proteomes:UP000239044}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UN-152 {ECO:0000313|EMBL:PRI16239.1,
RC ECO:0000313|Proteomes:UP000239044};
RA Yoshida M., Fukano H., Hoshino Y.;
RT "Draft genome sequence of Mycobacterium shigaense sp. nov.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000217736}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UN-152 {ECO:0000313|Proteomes:UP000217736};
RA Fukano H., Yoshida M., Kazumi Y., Ogura Y., Mitarai S., Hayashi T.,
RA Hoshino Y.;
RT "Complete Genome Sequence of Mycobacterium shigaense.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:BAX91473.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 32072 {ECO:0000313|EMBL:BAX91473.1};
RA Yoshida M., Fukano H., Ogura Y., Kazumi Y., Mitarai S., Hayashi T.,
RA Hoshino Y.;
RT "Complete Genome Sequence of Mycobacterium shigaense.";
RL Genome Announc. 6:e00552-18(2018).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; AP018164; BAX91473.1; -; Genomic_DNA.
DR EMBL; MWON01000004; PRI16239.1; -; Genomic_DNA.
DR KEGG; mshg:MSG_01315; -.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000217736; Chromosome.
DR Proteomes; UP000239044; Unassembled WGS sequence.
DR GO; GO:0106322; F:S-(hydroxymethyl)glutathione dehydrogenase NAD activity; IEA:UniProtKB-EC.
DR GO; GO:0106321; F:S-(hydroxymethyl)glutathione dehydrogenase NADP activity; IEA:UniProtKB-EC.
DR CDD; cd08283; FDH_like_1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:BAX91473.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 26..144
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 189..259
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 400 AA; 43050 MW; FC8E8039B2BEB9A7 CRC64;
MQAVTWHGKR DVRVDSVPDP KIEQPTDAIV EITSTNICGS DLHLYEVLGA FMKPGDILGH
EPMGIVREVG AETGDLRVGD RVVIPFQISC GSCHMCHHRL FTQCETTQVR DQGMGAALFG
YSELYGEVPG GQAELLRVPQ AQFTHIKVPV GPPDSRFVYL SDVLPTAWQA VAYADIPDGG
SVAVLGLGPI GDMAARIADH LGYRVVAVDL VPERLARAAK RGIHTIDLSR LDVPVGEAIR
ELTEGRGADS VIDAVGMESH GSPAAKFAQQ ATTILPDAIA KRFMQTAGVD RLNALYSAID
IVRRGGTISL IGVYGGMADP LPLLTLFDKQ VTLRMGQANV KRWVDDIMPL LTDDDPLGVD
DFATHVLPLD RAPHGYDIFQ KKKDGAVKVI LKPGLATNAS
//
