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Entry: A0A1Z4EP94_9MYCO
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ID   A0A1Z4EP94_9MYCO        Unreviewed;       272 AA.
AC   A0A1Z4EP94;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=dihydropteroate synthase {ECO:0000256|ARBA:ARBA00012458};
DE            EC=2.5.1.15 {ECO:0000256|ARBA:ARBA00012458};
GN   Name=folP1 {ECO:0000313|EMBL:BAX94720.1};
GN   ORFNames=B2J96_10585 {ECO:0000313|EMBL:PRI14922.1}, MSG_04606
GN   {ECO:0000313|EMBL:BAX94720.1};
OS   Mycobacterium shigaense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium simiae complex.
OX   NCBI_TaxID=722731 {ECO:0000313|EMBL:BAX94720.1, ECO:0000313|Proteomes:UP000217736};
RN   [1] {ECO:0000313|EMBL:PRI14922.1, ECO:0000313|Proteomes:UP000239044}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UN-152 {ECO:0000313|EMBL:PRI14922.1,
RC   ECO:0000313|Proteomes:UP000239044};
RA   Yoshida M., Fukano H., Hoshino Y.;
RT   "Draft genome sequence of Mycobacterium shigaense sp. nov.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000217736}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UN-152 {ECO:0000313|Proteomes:UP000217736};
RA   Fukano H., Yoshida M., Kazumi Y., Ogura Y., Mitarai S., Hayashi T.,
RA   Hoshino Y.;
RT   "Complete Genome Sequence of Mycobacterium shigaense.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:BAX94720.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JCM 32072 {ECO:0000313|EMBL:BAX94720.1};
RA   Yoshida M., Fukano H., Ogura Y., Kazumi Y., Mitarai S., Hayashi T.,
RA   Hoshino Y.;
RT   "Complete Genome Sequence of Mycobacterium shigaense.";
RL   Genome Announc. 6:e00552-18(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate =
CC         7,8-dihydropteroate + diphosphate; Xref=Rhea:RHEA:19949,
CC         ChEBI:CHEBI:17836, ChEBI:CHEBI:17839, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:72950; EC=2.5.1.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000012};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-
CC       dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-
CC       dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004763}.
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DR   EMBL; AP018164; BAX94720.1; -; Genomic_DNA.
DR   EMBL; MWON01000011; PRI14922.1; -; Genomic_DNA.
DR   KEGG; mshg:MSG_04606; -.
DR   Proteomes; UP000217736; Chromosome.
DR   Proteomes; UP000239044; Unassembled WGS sequence.
DR   GO; GO:0004156; F:dihydropteroate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00739; DHPS; 1.
DR   Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR   InterPro; IPR045031; DHP_synth-like.
DR   InterPro; IPR006390; DHP_synth_dom.
DR   InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR   InterPro; IPR000489; Pterin-binding_dom.
DR   NCBIfam; TIGR01496; DHPS; 1.
DR   PANTHER; PTHR20941; FOLATE SYNTHESIS PROTEINS; 1.
DR   PANTHER; PTHR20941:SF1; FOLIC ACID SYNTHESIS PROTEIN FOL1; 1.
DR   Pfam; PF00809; Pterin_bind; 1.
DR   SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR   PROSITE; PS00793; DHPS_2; 1.
DR   PROSITE; PS50972; PTERIN_BINDING; 1.
PE   4: Predicted;
KW   Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAX94720.1}.
FT   DOMAIN          1..257
FT                   /note="Pterin-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50972"
SQ   SEQUENCE   272 AA;  27712 MW;  49CEDE03535D5408 CRC64;
     MGVLNVTDDS FSDGGRYLDA DSAVAHGLAM AAAGAAIVDV GGESTRPGAV RIDPEAEASR
     VVPVVKDIAA QGITVSIDTM HADVARAALD SGARIVNDVS GGRADPAMAP LLAEAGVPWV
     LMHWRSVSAA EPHRAPHYRD VVAEVRAELL AGVDDAVAAG VDPAKVIIDP GLGFAKTGQH
     NWALLHALPE LVGTGVPVLL GASRKRFLGT LLGAPDGTPR PPDGRETATA VISALAALSG
     VWGVRVHDVR ASVDALKVVG AWAHGERAGC DG
//
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