ID A0A1Z4JMC2_LEPBY Unreviewed; 696 AA.
AC A0A1Z4JMC2;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:BAY57899.1};
GN ORFNames=NIES2135_47710 {ECO:0000313|EMBL:BAY57899.1};
OS Leptolyngbya boryana NIES-2135.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Leptolyngbyales; Leptolyngbyaceae;
OC Leptolyngbya group; Leptolyngbya.
OX NCBI_TaxID=1973484 {ECO:0000313|EMBL:BAY57899.1, ECO:0000313|Proteomes:UP000217895};
RN [1] {ECO:0000313|EMBL:BAY57899.1, ECO:0000313|Proteomes:UP000217895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2135 {ECO:0000313|EMBL:BAY57899.1,
RC ECO:0000313|Proteomes:UP000217895};
RA Hirose Y., Shimura Y., Fujisawa T., Nakamura Y., Kawachi M.;
RT "Genome sequencing of cyanobaciteial culture collection at National
RT Institute for Environmental Studies (NIES).";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AP018203; BAY57899.1; -; Genomic_DNA.
DR RefSeq; WP_017289509.1; NZ_AP018203.1.
DR AlphaFoldDB; A0A1Z4JMC2; -.
DR Proteomes; UP000217895; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR CDD; cd01988; Na_H_Antiporter_C; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR43562:SF4; NA(+)_H(+) ANTIPORTER NHAS5; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF00582; Usp; 2.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000217895};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..385
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 414..545
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
FT DOMAIN 553..679
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 696 AA; 75314 MW; 7262F2FAC9C2AD31 CRC64;
MLLLTAGLFQ EPIVAFVILL AVILVVPLIF ERLRLPGLVG LLAAGVALGP NGLNIFQTES
ETMNLLSDIG LIYLMFVAGL EIDIDQFTRT RNRSIGFGTF TFLVPLIVGT IVGRLFGFDW
NPAILIGSLF ASHTLLAYPI VSRLGIVNNE AVTVTIGATI FTDIGALLVL AICIGIHAGD
FTVFKLFTLL GSLGIYTIVI LVGFDKAGRE FFKRSGDEEG NQFLFVLLAV FLASVGAQLI
GVEKIVGAFL SGLAVNRVVG DSPVKEKVVF VGSVLFIPIF FVDMGLLIRV PVFIQSLSDP
KLLGLTIAIV VGLIFSKMAA AVLAKLAYRY SWTEMMVMGS LSLPQVAATL AATLVGYRAG
LLTEGVLNSV IVLMLVTSTL GPILTARFAT ELQAETVEDL PPTLADPVWI SQMTVLVPVY
NPNTEANLLE LAALIARSHS GRLIPFAVAF SQSHLNSSQM QERLDRSELL LERATQFAQS
FDVEVSPILR IDDRIAQGIT RASREHHANL IIMGWGRQSR FGERLFRTIV SDVLYAAPCP
VAVARLLKSP SQFQKILIPI ENLTLRSISA LQFALNIATA TNGQMTLMHV CGRTTSASKI
AWIRSQLDLL VEKLAPQVEQ IATEIVIIPE DDIGRAIVAA SKSFDLLILR SSQTPNTAGG
LILGNLVSQI SVQIQCSMIL FDEPEVVDRP LLLPNA
//
