ID A0A1Z4R464_9CYAN Unreviewed; 711 AA.
AC A0A1Z4R464;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:BAZ37251.1};
GN ORFNames=NIES4101_31720 {ECO:0000313|EMBL:BAZ37251.1};
OS Calothrix sp. NIES-4101.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Calotrichaceae;
OC Calothrix.
OX NCBI_TaxID=2005461 {ECO:0000313|EMBL:BAZ37251.1, ECO:0000313|Proteomes:UP000290974};
RN [1] {ECO:0000313|EMBL:BAZ37251.1, ECO:0000313|Proteomes:UP000290974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-4101 {ECO:0000313|EMBL:BAZ37251.1,
RC ECO:0000313|Proteomes:UP000290974};
RA Hirose Y., Shimura Y., Fujisawa T., Nakamura Y., Kawachi M.;
RT "Genome sequencing of cyanobaciteial culture collection at National
RT Institute for Environmental Studies (NIES).";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AP018280; BAZ37251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z4R464; -.
DR Proteomes; UP000290974; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR CDD; cd01988; Na_H_Antiporter_C; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR43562:SF4; NA(+)_H(+) ANTIPORTER NHAS5; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF00582; Usp; 2.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290974};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 22..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..394
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 425..556
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
FT DOMAIN 564..688
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 711 AA; 76589 MW; 150869870AF37469 CRC64;
MELISQVLAL EPTTNVLSKE PIVPFAILLV VILVVPTIFE RLRLPGMVGL LIAGVLLGPR
GWNLLNSDLA MMKVLSEIGL VYLMFVAGLE IDINQFRHTT NRSLGFGSFT FGVPLIVGTF
VGRIFGFDWN AAILIGSLFA SHTLLAYPII NRLGVVNNEA VIVTIGATVF TDISALLLLA
VCIAVHTAQL NPSNLMILLG CLTIYATVVL VGFDWAGKEF FRRSGEDEGN QFLFVLLAVF
LAAVGAQLIG VEKIVGAFLA GLAVNDTLGE GPVKEKVVFV GSVLFIPIFF VNLGLLVNLT
ALTRNVSALQ LTLFIVAGLI LSKFIAALLA KLIYHYNWQE VMTMWSLSIP QVGATLAATL
VGYRAGLLSE TVLTSIIILM LVTSTLGPLI TSRVAVGLNS SLTQIPTSVK SVLYPSLSPG
KNQYTVVVPI YNPQTQQYLI EMAALLAKQG NGKIVPLAIA TAAAHMDAPQ LEASLQRSER
LLIKANALSR VLNVNSESLL RIDDAFAPGI CRAAREQRAS LIVMGWGKRT GLRARLFGNV
IDSVLWSSHC PVAVTRLVES PKKIQRILVP IENLMSPTLQ PLHFAQILAE ANQAQVTVLN
VCERRTSSSK IAAKRSQLKL LVSKLAPLNP PDIQIIAHDN VAQAILQAAR LYDLVVLPFI
RNRTIPGGLA ISDVTTQLAR QLSCSIVMLG EPQRGQPVIL PTGVANTTAI V
//
