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Database: UniProt
Entry: A0A1Z4S3S3_9NOSO
LinkDB: A0A1Z4S3S3_9NOSO
Original site: A0A1Z4S3S3_9NOSO 
ID   A0A1Z4S3S3_9NOSO        Unreviewed;       463 AA.
AC   A0A1Z4S3S3;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   05-DEC-2018, entry version 7.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=NIES4103_19760 {ECO:0000313|EMBL:BAZ49364.1};
OS   Nostoc sp. NIES-4103.
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=2005458 {ECO:0000313|EMBL:BAZ49364.1, ECO:0000313|Proteomes:UP000218514};
RN   [1] {ECO:0000313|EMBL:BAZ49364.1, ECO:0000313|Proteomes:UP000218514}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-4103 {ECO:0000313|EMBL:BAZ49364.1,
RC   ECO:0000313|Proteomes:UP000218514};
RA   Hirose Y., Shimura Y., Fujisawa T., Nakamura Y., Kawachi M.;
RT   "Genome sequencing of cyanobaciteial culture collection at National
RT   Institute for Environmental Studies (NIES).";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; AP018288; BAZ49364.1; -; Genomic_DNA.
DR   Proteomes; UP000218514; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000218514};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218514}.
FT   DOMAIN      346    448       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    293    293       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     122    122       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     176    176       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     296    296       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     360    360       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   463 AA;  49710 MW;  98E8DDDCDD880858 CRC64;
     MRVCVIGTGY VGLVTGACLA HIGHDVICVD NNEEKVKLMK SGQSPIFEPG LSEIMQSAIQ
     AGTIQFTTDL AAGVAHGQIL FIAVGTPPLP TGESDTRYVE AVARGIGANL NGGYKVIVNK
     STVPIGSGDW VRMIVLDGIA ERQKTLVPAG GVAVEEKSAE LVAQFDVVSN PEFLREGSAV
     YDTFNPDRIV LGGNSPRAIA LMQELYTPIV ERKFAEDKSL PKVPVLVTDL SSAEMIKYAA
     NAFLATKISF INEVANICDR VGADVTQVAK GIGLDSRIGN KFLQAGIGWG GSCFPKDVSA
     LIHTADDYGY EAQLMKSAVS VNERQRLIAL EKLQQVLKIL KGKTVGLLGL TFKPDTDDMR
     DAPALNLIEQ LNRLGAKVKA YDPIVSQTGM RHGLTGVLVE TDAERLADGC DALVLVTEWQ
     QFSTLDYAKM AKLMSNPVII DGRNFLDPET LVRAGFQYVG IGR
//
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