ID A0A1Z4V3W6_9CYAN Unreviewed; 967 AA.
AC A0A1Z4V3W6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=NIES806_23330 {ECO:0000313|EMBL:BAZ86123.1};
OS Dolichospermum compactum NIES-806.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Aphanizomenonaceae;
OC Dolichospermum; Dolichospermum compactum.
OX NCBI_TaxID=1973481 {ECO:0000313|EMBL:BAZ86123.1, ECO:0000313|Proteomes:UP000218702};
RN [1] {ECO:0000313|EMBL:BAZ86123.1, ECO:0000313|Proteomes:UP000218702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-806 {ECO:0000313|EMBL:BAZ86123.1,
RC ECO:0000313|Proteomes:UP000218702};
RA Hirose Y., Shimura Y., Fujisawa T., Nakamura Y., Kawachi M.;
RT "Genome sequencing of cyanobaciteial culture collection at National
RT Institute for Environmental Studies (NIES).";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AP018316; BAZ86123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z4V3W6; -.
DR REBASE; 207453; Dco806ORF23330P.
DR OrthoDB; 564694at2; -.
DR Proteomes; UP000218702; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046819; MmeI_hel.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046817; MmeI_N.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF6; DNA METHYLTRANSFERASE A; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20465; MmeI_hel; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20464; MmeI_N; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:BAZ86123.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAZ86123.1}.
FT DOMAIN 7..176
FT /note="MmeI-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20464"
FT DOMAIN 184..256
FT /note="MmeI-like helicase spacer"
FT /evidence="ECO:0000259|Pfam:PF20465"
FT DOMAIN 336..592
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 787..846
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
FT REGION 719..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 110936 MW; 684837A27238290F CRC64;
MTDTPSKIRS FIEYSRTLKG DEKGEAQVFC DRLFQAFNHE GYKEAGAELE YRVKVKGKST
KFADLLWRPR LLLEMKKRGE KLEKHYQQAF EYWLELVPQR PKYVILCNFD QFWIYDFDIQ
LREPVDQVKL EDLPNRYTVL NFLFPENRKP LFNNNLVDVT RKAADNVAQV FNRLIERGEK
QEIAQRFILQ CVVSLFAEDI DLLPRGLFSE FLDDCRSNRI SSYDLIGGLF QQMGNQRPAP
QDSRYRDVPY FNAGVFSKVE PISLTRSEID LLASAATERW SKVEPAIFGT LFESSMGKEE
RHALGAHYTS PVDIQKVILP TIVRPWEERI DGATKLNELL ILRQELINFT VLDPACGSGN
FLYVAYRELK GLEAKLLTKI HENFGLKNRL SIGTMSLIKT TQFHGIDIKH FAVELAKVTL
MIAKKLALDE ENQLLDVAQM SLPIEIDRAL PLDNLDKNIR CDDALFCDWV TADAIIGNPP
YQSKNKMQQE YGVTYVSQVR ERYDEVPGRA DYCVYWFRRT HDALKEGGRA GLVGTNTIRQ
NYSREGGLDY IVNNGGTITE AVCTQVWSGS AAVHVSIVNW VKGEELGQKK LYTQIGDDKD
SPWEVLEIDK IGSALSAKLD VTQAKKLLVN VNSGACYQGQ THGHEGFLLT PQEAAIMIRQ
SKNNAEVIFP YLIADELIGG NPPIPQRYVI DFHPRNLMNC KKYSEPFKRI ESMVLPTREN
TAKEEQKRNE ELLQKNPKSK VNKHHQNFLS KWWLLSYHRG ELIEKITNIP RFICCGQVTK
RPVFEFISSS IRPNAALIVF PLSDDYSFGI LQSDIHWQWF TSRCSTLTAR FRYTSDTVFD
SFPFPQNPKL SQVKKVALAA VKLRQLRQEL MTEHKMSLRE LYRTLELPGK NPLRKAQEEL
DKAVRQAYGM EGTDDVLKFL LELNFAVADR EINNLPVVAP GLPPCVTNPS EFITDDCVKM
PEWNLVC
//
